Journal of Cardiovascular Translational Research

, Volume 3, Issue 6, pp 652–662

The Paracrine Effect: Pivotal Mechanism in Cell-Based Cardiac Repair

  • Simon Maltais
  • Jacques P. Tremblay
  • Louis P. Perrault
  • Hung Q. Ly
Article

DOI: 10.1007/s12265-010-9198-2

Cite this article as:
Maltais, S., Tremblay, J.P., Perrault, L.P. et al. J. of Cardiovasc. Trans. Res. (2010) 3: 652. doi:10.1007/s12265-010-9198-2

Abstract

Cardiac cell therapy has emerged as a controversial yet promising therapeutic strategy. Both experimental data and clinical applications in this field have shown modest but tangible benefits on cardiac structure and function and underscore that transplanted stem–progenitor cells can attenuate the postinfarct microenvironment. The paracrine factors secreted by these cells represent a pivotal mechanism underlying the benefits of cell-mediated cardiac repair. This article reviews key studies behind the paracrine effect related to the cardiac reparative effects of cardiac cell therapy.

Keywords

Paracrine EffectCardiac RepairStem–Progenitor CellsTherapy

Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Simon Maltais
    • 1
  • Jacques P. Tremblay
    • 2
  • Louis P. Perrault
    • 1
  • Hung Q. Ly
    • 3
  1. 1.Department of Cardiac Surgery, Montreal Heart InstituteUniversité de MontréalMontréalCanada
  2. 2.Department of Human Genetics, CHUQ-CHULLaval UniversitySte-FoyCanada
  3. 3.Department of Medicine, Montreal Heart InstituteUniversité de MontréalMontrealCanada