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Effects of testosterone and estradiol on anxiety and depressive-like behavior via a non-genomic pathway

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Abstract

Besides their known slow genomic effects, testosterone and estradiol have rapid effects in the brain. However, their impact on mood-related behavior is not clear. The aim of this study was to investigate the non-genomic pathway of testosterone and estradiol in the amygdala in relation to anxiety and depressive-like behavior. Sham-operated and gonadectomized male rats (GDX) supplemented with testosterone propionate, estradiol, or olive oil were used. Five minutes after administration, anxiety and depression-like behavior were tested. Estradiol increased anxiolytic behavior in the open-field test compared to the GDX group, but administration of testosterone had no significant effect. Besides, c-Fos expression in the medial nucleus of the amygdala significantly increased after testosterone treatment compared to the GDX group, while no significant difference was observed in the central and the basolateral nuclei of the amygdala in the testosterone-treated group compared to the GDX group. In conclusion, estradiol had an anxiolytic effect via a rapid pathway, but no rapid effect of testosterone on anxiety was found. Further studies elucidating whether the rapid effect is mediated by a non-genomic pathway are needed.

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Authors and Affiliations

  1. Institute of Molecular Biomedicine, Faculty of Medicine, Comenius University, Bratislava, Slovakia

    Barbora Filova, Maria Malinova, Janka Babickova, Lubomira Tothova, Peter Celec & Julius Hodosy

  2. Institute of Physiology, Faculty of Medicine, Comenius University, Bratislava, Slovakia

    Daniela Ostatnikova & Julius Hodosy

  3. Institute of Pathophysiology, Faculty of Medicine, Comenius University, Bratislava, Slovakia

    Peter Celec

  4. Department of Molecular Biology, Faculty of Natural Sciences, Comenius University, Bratislava, Slovakia

    Peter Celec

  5. Center for Molecular Medicine, Slovak Academy of Sciences, Bratislava, Slovakia

    Janka Babickova, Lubomira Tothova, Peter Celec & Julius Hodosy

Authors
  1. Barbora Filova
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  2. Maria Malinova
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  3. Janka Babickova
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  7. Julius Hodosy
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Correspondence to Julius Hodosy.

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Filova, B., Malinova, M., Babickova, J. et al. Effects of testosterone and estradiol on anxiety and depressive-like behavior via a non-genomic pathway. Neurosci. Bull. 31, 288–296 (2015). https://doi.org/10.1007/s12264-014-1510-8

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  • DOI: https://doi.org/10.1007/s12264-014-1510-8

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