Neuroscience Bulletin

, Volume 30, Issue 2, pp 271–281

Oxidative stress in Alzheimer’s disease

Authors

  • Zhichun Chen
    • Department of Neurology, Zhongshan Hospital; The State Key Laboratory of Medical NeurobiologyFudan University
    • The Institutes of Brain ScienceFudan University
    • Department of Neurology, Zhongshan Hospital; The State Key Laboratory of Medical NeurobiologyFudan University
    • The Institutes of Brain ScienceFudan University
Review

DOI: 10.1007/s12264-013-1423-y

Cite this article as:
Chen, Z. & Zhong, C. Neurosci. Bull. (2014) 30: 271. doi:10.1007/s12264-013-1423-y

Abstract

Oxidative stress plays a significant role in the pathogenesis of Alzheimer’s disease (AD), a devastating disease of the elderly. The brain is more vulnerable than other organs to oxidative stress, and most of the components of neurons (lipids, proteins, and nucleic acids) can be oxidized in AD due to mitochondrial dysfunction, increased metal levels, inflammation, and β-amyloid (Aβ) peptides. Oxidative stress participates in the development of AD by promoting Aβ deposition, tau hyperphosphorylation, and the subsequent loss of synapses and neurons. The relationship between oxidative stress and AD suggests that oxidative stress is an essential part of the pathological process, and antioxidants may be useful for AD treatment.

Keywords

Alzheimer’s diseaseoxidative stressβ-amyloidtaumetalsantioxidants

Copyright information

© Shanghai Institutes for Biological Sciences, CAS and Springer-Verlag Berlin Heidelberg 2014