Neuroscience Bulletin

, Volume 29, Issue 6, pp 779–787

Research progress on the NLRP3 inflammasome and its role in the central nervous system

Review

DOI: 10.1007/s12264-013-1328-9

Cite this article as:
Liu, SB., Mi, WL. & Wang, YQ. Neurosci. Bull. (2013) 29: 779. doi:10.1007/s12264-013-1328-9

Abstract

The NLRP3 inflammasome, which consists of the NLRP3 (nucleotide-binding oligomerization domain (Nod)-like receptor 3) scaffold, the ASC (apoptosis-associated speck-like protein containing a CARD) adaptor and procaspase- 1, is assembled after the cytoplasmic LRRs (leucine-rich repeats) of NLRP3 sense pathogens or danger signals. The NLRP3 inflammasome controls the activation of the proteolytic enzyme caspase-1. Caspase-1 in turn regulates the maturation of the proinflammasome cytokines IL-1β and IL-18, which leads to an inflammatory response. The inflammasome plays an important role in the development of Alzheimer’s disease and bacterial meningitis, and the NLRP3 inflammasome may become a new target for the prevention and treatment of central nervous system diseases.

Keywords

NLRP3 inflammasome central nervous system 

Copyright information

© Shanghai Institutes for Biological Sciences, CAS and Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  1. 1.Department of Integrative Medicine and Neurobiology, Institute of Acupuncture Research, State Key Laboratory of Medical Neurobiology, Institutes of Brain Science, Shanghai Medical CollegeFudan UniversityShanghaiChina

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