Neuroscience Bulletin

, Volume 28, Issue 2, pp 91–99

Population coding of somatic sensations

Review

DOI: 10.1007/s12264-012-1201-2

Cite this article as:
Ma, Q. Neurosci. Bull. (2012) 28: 91. doi:10.1007/s12264-012-1201-2

Abstract

The somatic sensory system includes a variety of sensory modalities, such as touch, pain, itch, and temperature sensitivity. T The coding of these modalities appears to be best explained by the population-coding theory, which is composed of the following features. First, an individual somatic sensory afferent is connected with a specific neural circuit or network (for simplicity, a sensory-labeled line), whose isolated activation is sufficient to generate one specific sensation under normal conditions. Second, labeled lines are interconnected through local excitatory and inhibitory interneurons. As a result, activation of one labeled line could modulate, or provide gate control of, another labeled line. Third, most sensory fibers are polymodal, such that a given stimulus placed onto the skin often activates two or multiple sensory-labeled lines; crosstalk among them is needed to generate one dominant sensation. Fourth and under pathological conditions, a disruption of the antagonistic interaction among labeled lines could open normally masked neuronal pathways, and allow a given sensory stimulus to evoke a new sensation, such as pain evoked by innocuous mechanical or thermal stimuli and itch evoked by painful stimuli. As a result of this, some sensory fibers operate along distinct labeled lines under normal versus pathological conditions. Thus, a better understanding of the neural network underlying labeled line crosstalk may provide new strategies to treat chronic pain and itch.

Keywords

developmental neurobiologydorsal root ganglionpain pathwaysitchspinal dorsal horn

Copyright information

© Shanghai Institutes for Biological Sciences, CAS and Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  1. 1.Dana-Farber Cancer Institute and Department of NeurobiologyHarvard Medical SchoolBostonUSA