, Volume 27, Issue 4, pp 275-285
Date: 05 Aug 2011

Cannabinoid as a neuroprotective strategy in perinatal hypoxic-ischemic injury

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Abstract

Perinatal hypoxia-ischemia remains the single most important cause of brain injury in the newborn, leading to death or lifelong sequelae. Because of the fact that there is still no specific treatment for perinatal brain lesions due to the complexity of neonatal hypoxic-ischemic pathophysiology, the search of new neuroprotective therapies is of great interest. In this regard, therapeutic possibilities of the endocannabinoid system have grown lately. The endocannabinoid system modulates a wide range of physiological processes in mammals and has demonstrated neuroprotective effects in different paradigms of acute brain injury, acting as a natural neuroprotectant. Concerning perinatal asphyxia, the neuroprotective role of this endogenous system is emerging these years. The present review mainly focused on the current knowledge of the cannabinoids as a new neuroprotective strategy against perinatal hypoxic-ischemic brain injury.

摘要

围产期缺血缺氧一直是引起新生儿脑损伤的首要因素, 往往导致死亡或终生后遗症。 由于新生儿缺血缺氧性脑损伤的病理复杂性, 目前还没有针对此病的特定疗法。 因此, 寻找新的神经保护性疗法正日益引起研究者的关注。 在哺乳动物体内, 大麻素系统能调节大范围的生理过程, 而且在不同类型的急性脑损伤中也具有神经保护作用。 近几年的研究表明, 内源性大麻素系统在围产期窒息中也扮演着神经保护者的角色。 本文主要就大麻素作为一种新的治疗策略在围产期缺血缺氧性脑损伤中的神经保护作用做一综述。