Preventive effect of estrogen on depression-like behavior induced by chronic restraint stress
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- Li, W., Li, QJ. & An, SC. Neurosci. Bull. (2010) 26: 140. doi:10.1007/s12264-010-0609-9
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To investigate the roles of estrogen and kalirin-7 in chronic restraint stress (CRS)-induced depression and the pathophysiological mechanism of depression.
Healthy female mice from Institute of Cancer Research (ICR) were randomly divided into 3 groups: control group, CRS group, and estrogen + CRS group. CRS was used to establish the animal model of depression. Forced swimming test and immunohistochemistry method were utilized to investigate the animal behavior and kalirin-7 expression in the hippocampus, respectively.
Compared with the control group, the CRS mice displayed depression-like behaviors, including a significant reduction in body weight, a significant increase in immobility time in forced swimming test, and a dramatic decrease in kalirin-7 expression in the hippocampus. However, administration of estrogen attenuated the CRS-induced negative behaviors, and simultaneously increased kalirin-7 expression.
Estrogen replacement therapy (ERT) could prevent CRS-induced depression-like behaviors in female ICR mice. Besides, kalirin-7 also plays a role in preventing CRS-induced depression-like behaviors.
Keywordschronic restraint stressdepressionestrogenneural plasticitykalirin-7
采用慢性束缚应激性抑郁动物模型, 运用强迫游泳测试和免疫组织化学方法, 分别检测动物行为学表现及海马中kalirin-7 蛋白的表达。
慢性束缚应激能显著降低动物体重、 延长游泳不动时间、 抑制海马中kalirin-7 蛋白的表达。 注射雌激素能明显改善动物抑郁样行为, 并且海马kalirin-7 表达显著增加。
慢性束缚应激能诱发产生抑郁样行为, 而雌激素替代疗法则能预防慢性束缚应激性抑郁的发生。 此外, kalirin-7 在防止慢性束缚应激性抑郁的发生中起到重要作用。