Firing activity of locus coeruleus noradrenergic neurons increases in a rodent model of Parkinsonism
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- Wang, T., Zhang, QJ., Liu, J. et al. Neurosci. Bull. (2009) 25: 15. doi:10.1007/s12264-009-1023-z
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To investigate the changes in the firing activity of noradrenergic neurons in the locus coeruleus (LC) in a rat model of Parkinson disease (PD).
2 and 4 weeks after unilateral lesion of the nigrostriatal pathway in the rat by local injection of 6-hydroxydopamine (6-OHDA) into the right substantia nigra pars compacta (SNc), the firing activity of noradrenergic neurons in LC was recorded by extracellular single unit recording.
The firing rate of LC noradrenergic neurons increased significantly 2 and 4 weeks after 6-OHDA lesions compared to normal rats, respectively (P < 0.05). The percentage of irregularly firing neurons was obviously higher than that of normal rats during the fourth week after SNc lesion (P < 0.05).
LC noradrenergic neurons are overactive and more irregular in 6-OHDA-lesioned rats. These changes suggest an implication of the LC in the pathophysiological mechanism of PD.
Keywordslocus coeruleus6-hydroxydopamineParkinson diseaseelectrophysiology
6-羟多巴胺损毁术后第2周和第4周, 蓝斑核肾上腺素能神经元放电频率比对照组显著增加(P < 0.05)。 损毁术后第4周, 蓝斑核呈不规则放电的神经元比例显著高于对照组(P < 0.05)。
6- 羟多巴胺损毁术后, 大鼠蓝斑核肾上腺素能神经元活动增强, 且更不规则, 提示蓝斑核参与帕金森病的发病。