Genes & Nutrition

, Volume 7, Issue 1, pp 83–89

Vitamin E succinate inhibits survivin and induces apoptosis in pancreatic cancer cells

Authors

  • Dorrelyn Patacsil
    • Cancer Research Laboratory, Department of Biological and Environmental SciencesUniversity of the District of Columbia
  • Sylvester Osayi
    • Cancer Research Laboratory, Department of Biological and Environmental SciencesUniversity of the District of Columbia
  • Anh Thu Tran
    • Cancer Research Laboratory, Department of Biological and Environmental SciencesUniversity of the District of Columbia
  • Francisco Saenz
    • Cancer Research Laboratory, Department of Biological and Environmental SciencesUniversity of the District of Columbia
  • Lydia Yimer
    • Cancer Research Laboratory, Department of Biological and Environmental SciencesUniversity of the District of Columbia
  • Ayesha N. Shajahan
    • Lombardi Comprehensive Cancer CenterGeorgetown University
  • Prafulla C. Gokhale
    • Lombardi Comprehensive Cancer CenterGeorgetown University
  • Mukesh Verma
    • Methods and Technologies Branch, Epidemiology and Genetics Research Program, Division of Cancer Control and Population SciencesNational Cancer Institute
  • Robert Clarke
    • Lombardi Comprehensive Cancer CenterGeorgetown University
  • Subhash C. Chauhan
    • Cancer Biology Research CenterSanford Research/University of South Dakota
    • Cancer Research Laboratory, Department of Biological and Environmental SciencesUniversity of the District of Columbia
    • Lombardi Comprehensive Cancer CenterGeorgetown University
Research Paper

DOI: 10.1007/s12263-011-0242-x

Cite this article as:
Patacsil, D., Osayi, S., Tran, A.T. et al. Genes Nutr (2012) 7: 83. doi:10.1007/s12263-011-0242-x

Abstract

Pancreatic cancer is the fourth leading cause of cancer-related deaths in the United States. Identifying novel chemotherapeutic and chemopreventive approaches is critical in the prevention and treatment of cancers such as pancreatic cancer. Vitamin E succinate (VES) is a redox-silent analog of the fat-soluble vitamin alpha-tocopherol. In the present study, we explored the antiproliferative action of VES and its effects on inhibitor of apoptosis proteins in pancreatic cancer cells. We show that VES inhibits cell proliferation and induces apoptosis in pancreatic cancer cells. Further, we demonstrate that VES downregulates the expression of survivin and X-linked inhibitor of apoptosis proteins. The apoptosis induced by VES was augmented by siRNA-mediated inhibition of survivin in PANC-1 cells. In summary, our results suggest that VES targets survivin signaling and induces apoptosis in pancreatic cancer cells.

Keywords

Vitamin EVitamin E succinateSurvivinPancreatic cancerApoptosis

Copyright information

© Springer-Verlag 2011