Genes & Nutrition

, Volume 7, Issue 1, pp 83–89

Vitamin E succinate inhibits survivin and induces apoptosis in pancreatic cancer cells

  • Dorrelyn Patacsil
  • Sylvester Osayi
  • Anh Thu Tran
  • Francisco Saenz
  • Lydia Yimer
  • Ayesha N. Shajahan
  • Prafulla C. Gokhale
  • Mukesh Verma
  • Robert Clarke
  • Subhash C. Chauhan
  • Deepak Kumar
Research Paper

DOI: 10.1007/s12263-011-0242-x

Cite this article as:
Patacsil, D., Osayi, S., Tran, A.T. et al. Genes Nutr (2012) 7: 83. doi:10.1007/s12263-011-0242-x

Abstract

Pancreatic cancer is the fourth leading cause of cancer-related deaths in the United States. Identifying novel chemotherapeutic and chemopreventive approaches is critical in the prevention and treatment of cancers such as pancreatic cancer. Vitamin E succinate (VES) is a redox-silent analog of the fat-soluble vitamin alpha-tocopherol. In the present study, we explored the antiproliferative action of VES and its effects on inhibitor of apoptosis proteins in pancreatic cancer cells. We show that VES inhibits cell proliferation and induces apoptosis in pancreatic cancer cells. Further, we demonstrate that VES downregulates the expression of survivin and X-linked inhibitor of apoptosis proteins. The apoptosis induced by VES was augmented by siRNA-mediated inhibition of survivin in PANC-1 cells. In summary, our results suggest that VES targets survivin signaling and induces apoptosis in pancreatic cancer cells.

Keywords

Vitamin EVitamin E succinateSurvivinPancreatic cancerApoptosis

Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  • Dorrelyn Patacsil
    • 1
  • Sylvester Osayi
    • 1
  • Anh Thu Tran
    • 1
  • Francisco Saenz
    • 1
  • Lydia Yimer
    • 1
  • Ayesha N. Shajahan
    • 2
  • Prafulla C. Gokhale
    • 2
  • Mukesh Verma
    • 4
  • Robert Clarke
    • 2
  • Subhash C. Chauhan
    • 3
  • Deepak Kumar
    • 1
    • 2
  1. 1.Cancer Research Laboratory, Department of Biological and Environmental SciencesUniversity of the District of ColumbiaWashingtonUSA
  2. 2.Lombardi Comprehensive Cancer CenterGeorgetown UniversityWashingtonUSA
  3. 3.Cancer Biology Research CenterSanford Research/University of South DakotaSioux FallsUSA
  4. 4.Methods and Technologies Branch, Epidemiology and Genetics Research Program, Division of Cancer Control and Population SciencesNational Cancer InstituteBethesdaUSA