Genes & Nutrition

, Volume 6, Issue 2, pp 109–115

Modulation of inflammatory signaling pathways by phytochemicals in ovarian cancer

  • Mi-Kyung Kim
  • Kidong Kim
  • Jae Yong Han
  • Jeong Mook Lim
  • Yong Sang Song
Review

DOI: 10.1007/s12263-011-0209-y

Cite this article as:
Kim, MK., Kim, K., Han, J.Y. et al. Genes Nutr (2011) 6: 109. doi:10.1007/s12263-011-0209-y

Abstract

Inflammation has been suggested to be involved in cancer development and progression. Many clinical and experimental studies have shown that inflammation could contribute to ovarian carcinogenesis through activation of the NF-κB and AP-1 pathways by chronic inflammatory mediators. Phytochemicals, which are natural compounds derived from fruits and vegetables, have shown anti-inflammatory and anti-cancer effects. Due to their relatively low toxicity and easy accessibility, phytochemicals have been investigated for their chemopreventive potential against various cancers. In this review, we discuss the role of phytochemicals in preventing ovarian cancer through anti-inflammatory mechanisms.

Keywords

PhytochemicalsOvarian cancerAnti-inflammationChemoprevention

Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  • Mi-Kyung Kim
    • 1
  • Kidong Kim
    • 2
  • Jae Yong Han
    • 3
  • Jeong Mook Lim
    • 3
  • Yong Sang Song
    • 1
    • 3
    • 4
  1. 1.Department of Obstetrics and GynecologySeoul National University College of MedicineSeoulRepublic of Korea
  2. 2.Department of Obstetrics and Gynecology, Korea Cancer Center HospitalKorea Institute of Radiological and Medical SciencesSeoulRepublic of Korea
  3. 3.Major in Biomodulation, WCU and Department of Agricultural BiotechnologySeoul National UniversitySeoulRepublic of Korea
  4. 4.Cancer Research InstituteSeoul National University College of MedicineSeoulRepublic of Korea