Genes & Nutrition

, Volume 5, Issue 1, pp 89–96

Effects of the Sri Lankan medicinal plant, Salacia reticulata, in rheumatoid arthritis

  • Yuusuke Sekiguchi
  • Hiroshi Mano
  • Sachie Nakatani
  • Jun Shimizu
  • Masahiro Wada
Research Paper

DOI: 10.1007/s12263-009-0144-3

Cite this article as:
Sekiguchi, Y., Mano, H., Nakatani, S. et al. Genes Nutr (2010) 5: 89. doi:10.1007/s12263-009-0144-3
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Abstract

Salacia reticulata is a native plant of Sri Lanka. In the traditional medicine of Sri Lanka and India, Salacia reticulata bark is considered orally effective in the treatment of rheumatism, gonorrhea, skin disease and diabetes. We have investigated, both in vivo and in vitro, whether the leaf of Salacia reticulata (SRL) can ameliorate collagen antibody-induced arthritis (CAIA) in mice as the rheumatoid arthritis (RA) model. The mice were fed a lard containing chow diet (AIN-93G) or the same diet containing 1% (w/w) SRL powder. All mice were bred for 23 days. On day 7 or 14 after LPS injection, mice were killed, and tissue and blood samples were collected. Histological analysis was performed, and serum levels of inflammatory mediators and the mRNA levels of inflammation-related genes and osteoclast-related genes were measured. SRL treatment ameliorated the rapid initial paw swelling, inflammatory cells infiltration, skeletal tissues damage, osteoclast activation and the mRNA levels for osteoclast-related genes compared with the CAIA mice. However, the serum and mRNA levels of inflammatory mediators did not differ between the CAIA mice and the SRL-treated mice. SRL might reduce the inflammatory cells induction and skeletal tissue degradation by CAIA by the regulating osteoclastogenesis.

Keywords

CAIAOsteoclastPannusRANKLRheumatoid arthritisSalacia reticulata

Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  • Yuusuke Sekiguchi
    • 1
  • Hiroshi Mano
    • 1
  • Sachie Nakatani
    • 1
  • Jun Shimizu
    • 1
  • Masahiro Wada
    • 1
  1. 1.Department of Clinical Dietetics and Human Nutrition, Faculty of Pharmaceutical SciencesJosai UniversitySaitamaJapan