Genes & Nutrition

, Volume 3, Issue 1, pp 29–34

The role of microenvironment in tumor angiogenesis


DOI: 10.1007/s12263-008-0076-3

Cite this article as:
Ribatti, D. & Vacca, A. Genes Nutr (2008) 3: 29. doi:10.1007/s12263-008-0076-3


Tumor microenvironment is essential for tumor cell proliferation, angiogenesis, invasion and metastasis through its provision of survival signals, secretion of growth and pro-angiogenic factors, and direct adhesion molecule interactions. This review examines its importance in the induction of an angiogenic response in tumors and in multiple myeloma. The encouraging results of pre-clinical and clinical trials in which tumors have been treated by targeting the tumor microenvironment are also discussed.


AngiogenesisAnti-angiogenesisMetastasisMicroenvironmentMultiple myelomaTumor growth

Copyright information

© Springer-Verlag 2008

Authors and Affiliations

  1. 1.Department of Human Anatomy and HistologyUniversity of Bari Medical SchoolBariItaly
  2. 2.Department of Biomedical Sciences and Human OncologyUniversity of Bari Medical SchoolBariItaly