The role of microenvironment in tumor angiogenesis
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- Ribatti, D. & Vacca, A. Genes Nutr (2008) 3: 29. doi:10.1007/s12263-008-0076-3
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Tumor microenvironment is essential for tumor cell proliferation, angiogenesis, invasion and metastasis through its provision of survival signals, secretion of growth and pro-angiogenic factors, and direct adhesion molecule interactions. This review examines its importance in the induction of an angiogenic response in tumors and in multiple myeloma. The encouraging results of pre-clinical and clinical trials in which tumors have been treated by targeting the tumor microenvironment are also discussed.