, Volume 2, Issue 4, pp 313-317
Date: 28 Nov 2007

NF-κB and Nrf2 as prime molecular targets for chemoprevention and cytoprotection with anti-inflammatory and antioxidant phytochemicals

Rent the article at a discount

Rent now

* Final gross prices may vary according to local VAT.

Get Access
This is an excerpt from the content

Chemoprevention with dietary phytochemicals

Cancer is a multifactorial heterogeneous disease characterized by multistage nature of pathogenesis. Over the past two or three decades, we have witnessed an enormous progress in the development of a vast variety of anticancer drugs and strategies. Nonetheless, we do not have magic bullets that can completely and selectively destroy malignant cells. Since neoplastic transformation, in general, is a relatively lengthy process that may take more than decades, there are ample opportunities to intervene in the pathogenesis of cancer, especially at early phases of oncogenesis. One such strategy is chemoprevention, an attempt to use either naturally occurring or synthetic substances, or their mixtures, to block, retard or even reverse the process of carcinogenesis. Numerous substances present in our daily diet, including fruits, vegetables, grains, spices, and seeds, have been shown to be effective in preventing cancer. Besides antioxidants, many pl