, Volume 2, Issue 1, pp 151-154
Date: 26 Sep 2007

Effect of supplementation with vitamin E and C on plasma hsCRP level and cobalt–albumin binding score as markers of plasma oxidative stress in obesity

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Introduction

About 50% of patients presenting acute coronary syndrome not displayed classical risk factors, remaining inaccessible for prevention. Plasma hsCRP [1] and cobalt–albumin binding (ABSU) test [2] were recently introduced as more informative cardiovascular risk markers. Ischemia modified albumin (IMA) assessed with ABSU test, appears to be an indicator of oxidative stress, may not be specific for cardiac ischemia. Data about IMA concentrations in noncardiac ischemia are limited. Vitamin E and C, potent antioxidants have several anti-atherogenic effects [3].

The aim of the study

The aim of study was to assess the effects of short-term dietary supplementation with vitamin E and C on the relation between plasma hsCRP, IMA level and oxidative stress/antioxidant capacity parameters.

Patients and methods

Forty-four cardiovascular event-free obese men without others CHD risk factors, without symptoms of inflammatory disease and the control group of normoweight healthy subjects (n = 18) w ...