Skip to main content

Advertisement

SpringerLink
Log in

A Comparative Study of Honey and Phenytoin Dressings for Chronic Wounds

  • Original Article
  • Published:
Indian Journal of Surgery Aims and scope Submit manuscript

Abstract

Chronic wounds are a common problem faced by health care professionals, both in the community and in the hospital setting. The aim of this study was to evaluate the use of honey and phenytoin with respect to the process of wound healing, eradication of infection, pain relief and hospital stay. The study included 150 patients, 3 groups of 50 each (group A, honey dressing; group B, phenytoin dressing; group C, saline dressing). The appearance of granulation tissue was faster with significant wound area reduction after 3 weeks in groups A and B compared to group C. Eradication of infection was evident earlier in the honey- and phenytoin-treated groups along with significant pain relief as compared to that of group C. The outcomes of the use of honey and phenytoin as wound dressings are beneficial and comparable. Honey provides quicker pain relief and removes malodour more effectively.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

Similar content being viewed by others

References

  1. Hasamnis AA, Mohanty BK, Muralikrishna, Patil S (2010) Evaluation of wound healing effect of topical phenytoin on excisional wound in albino rats. J Young Pharm 2:59–62

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Werdin F, Tenenhaus M, Rennekampff HO (2008) Chronic wound care. Lancet 372:1860–1862

    Article  PubMed  Google Scholar 

  3. Sharma RK, John JR (2012) Role of stem cells in the management of chronic wounds. Indian J Plast Surg 45:237–243

    Article  PubMed  PubMed Central  Google Scholar 

  4. Archer HG, Barnett S, Irving S, Middleton KR, Seal DV (1990) A controlled model of moist wound healing; comparison between semipermeable film, antiseptics and sugar paste. J Exp Pathol 71:155–170

    CAS  Google Scholar 

  5. Lawrence JC (1999) Honey and wound bacteria: editorial. J Wound Care 8(4):155

    Article  CAS  PubMed  Google Scholar 

  6. Kimball OP, Horan TN (1939) The use of Dilantin in the treatment of epilepsy. Ann Intern Med 13:787–793

    Article  Google Scholar 

  7. Molan PC (2006) Using honey in wound care. Int J Clin Aromather 3(2):21–24

    Google Scholar 

  8. Dustmann JH (1979) Antibacterial effect of honey. Apicata 14(1):7–11

    Google Scholar 

  9. White JW, Subers MH, Schepartz AI (1963) The identification of inhibine, the antibacterial factor in honey as hydrogen peroxide and its origin in a honey glucose-oxidase system. Biochim Biophys Acta 73:53–70

    Google Scholar 

  10. Frankel S, Robinson GE, Berenbaum MR (1998) Antioxidant capacity and correlated characteristics of 14 uniforal honeys. J Apic Res 37(1):27–31

    CAS  Google Scholar 

  11. Kaufman T, Eichenlaub EH, Angel MF, Levin M, Futrell JW (1985) Topical acidification promotes healing of experimental deep partial thickness skin burns: a randomised double-blind preliminary study. Burns Incl Therm Inj 12(2):84–90

    Article  CAS  PubMed  Google Scholar 

  12. Efem SE (1988) Clinical observations on the wound healing properties of honey. Br J Surg 75(7):679–681

    Article  CAS  PubMed  Google Scholar 

  13. Molan PC (2002) Re‐introducing honey in the management of wounds and ulcers—theory and practice. Ostomy Wound Manage 48:28–40

    PubMed  Google Scholar 

  14. Haynes JS, Callaghan R (2011) Properties of honey: its mode of action and clinical outcomes. Wounds UK 7(1):50–57

    Google Scholar 

  15. Visavadia BG, Honetsett J, Danford MH (2008) Manuka honey dressing: an effective treatment for chronic wound infections. Br J Oral Maxillofac Surg 46(1):55–56

    Article  PubMed  Google Scholar 

  16. Anstead GM, Hart LM, Sunahara JF, Liter MF (1996) Phenytoin in wound healing. Ann Pharmacother 30:768–775

    CAS  PubMed  Google Scholar 

  17. Tauro LF, Shetty P, D’souza NT, Mohammed S, Sucharita S (2013) A comparative study of efficacy of topical phenytoin vs conventional wound care in diabetic ulcers. Int J Mol Med Sci 3(8):65–71

    Google Scholar 

  18. Modaghegh S, Salchian B, Tavassoli M, Djamshidi A, Rezai AS (1989) Use of phenytoin in healing of war and non-war wounds. A pilot study of 25 cases. Int J Dermatol 28:347–350

    Article  CAS  PubMed  Google Scholar 

  19. Rhodes RS, Heyneman CA, Culberston VL, Wilson SF, Phatak HM (2001) Topical phenytoin treatment of stage II decubitus ulcers in the elderly. Ann Pharmacother 35(6):675–681

    Article  CAS  PubMed  Google Scholar 

  20. Medhi B, Puri A, Upadhyay S, Kaman L (2008) Topical application of honey in the treatment of wound healing: a meta-analysis. J K Sci 10(4):166–169

    Google Scholar 

  21. Vijaya Kumari K, Nishteswar K (2012) Wound healing activity of honey: a pilot study. AYU 33(3):374–377

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  22. Udwadia TE (2011) Ghee and honey dressing for infected wounds. Indian J Surg 73(4):278–283

    Article  PubMed  PubMed Central  Google Scholar 

  23. Molan PC, Betts JA (2004) Clinical usage of honey as a wound dressing: an update. J Wound Care 13(9):353–356

    Article  CAS  PubMed  Google Scholar 

  24. Bansal NK, Mukul (1993) Comparison of typical phenytoin with normal saline in the treatment of chronic trophic ulcers in leprosy. Int J Dermatol 32:210–213

    Article  CAS  PubMed  Google Scholar 

  25. Pendse AK, Sharma A, Sodani A, Hada S (1993) Topical phenytoin in wound healing. Int J Dermatol 32:214–217

    Article  CAS  PubMed  Google Scholar 

Download references

Conflict of Interest

Nil

Author information

Authors and Affiliations

  1. Dr. D.Y. Patil Medical College, Hospital & Research Centre, A-2/103, Shivranjan Towers, Someshwarwadi, Pashan, Pune, 411008, India

    Siddharth P. Dubhashi & Rajat D. Sindwani

Authors
  1. Siddharth P. Dubhashi
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Rajat D. Sindwani
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Siddharth P. Dubhashi.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Dubhashi, S.P., Sindwani, R.D. A Comparative Study of Honey and Phenytoin Dressings for Chronic Wounds. Indian J Surg 77 (Suppl 3), 1209–1213 (2015). https://doi.org/10.1007/s12262-015-1251-6

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12262-015-1251-6

Keywords

Search

Navigation