Biotechnology and Bioprocess Engineering

, Volume 17, Issue 3, pp 427–438

Liver tissue engineering: Recent advances in the development of a bio-artificial liver

Review Paper

DOI: 10.1007/s12257-012-0047-9

Cite this article as:
Lee, J.S. & Cho, SW. Biotechnol Bioproc E (2012) 17: 427. doi:10.1007/s12257-012-0047-9


Orthotopic liver transplantation is the most common treatment for patients with end-stage liver failure. However, liver transplantation is greatly limited by a donor shortage. Liver tissue engineering may offer a promising strategy to solve this problem by providing transplantable, bioartificial livers. Diverse types of cells, biomaterials, and growth factor delivery systems have been tested for efficient regeneration of liver tissues that possess hepatic functions comparable to native livers. This article reviews recent advances in liver tissue engineering and describes cell sources, biomaterial scaffolds, and growth factor delivery systems that are currently being used to improve the regenerative potential of tissue-engineered livers.


liver tissue engineeringbiomaterialsscaffoldshepatocytesstem cellsgrowth factor delivery

Copyright information

© The Korean Society for Biotechnology and Bioengineering and Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  1. 1.Department of BiotechnologyYonsei UniversitySeoulKorea