Therapy optimisation studies in pediatric neurooncology – historical perspectives and future directions


DOI: 10.1007/s12254-011-0312-1

Cite this article as:
Benesch, M. memo (2011) 4(Suppl 3): 19. doi:10.1007/s12254-011-0312-1


Risk-adapted treatment stratification is a major characteristic of therapy optimisation studies for the treatment of benign and malignant childhood brain tumours. Thus far a patient having unfavourable risk factors ultimately requires a more intensive treatment in contrast to a patient with a more favourable risk profile. Several neuro-oncological therapy optimisation studies for children with brain tumours were recently initiated for patients with intracranial germ-cell tumours, with relapsed or refractory high-grade gliomas and for standard-risk or low-risk medulloblastoma to include biological parameters. Since our knowledge about the molecular biology of brain tumours is rapidly growing, molecular-based risk stratification will be used also for other brain tumour subtypes in the near future.


Childhood brain tumours Therapy optimisation PNET Medulloblastoma SIOP HIT 

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© Springer-Verlag 2011

Authors and Affiliations

  1. 1.Division of Paediatric Haematology/Oncology, Department of Paediatrics and Adolescent MedicineMedical University of GrazGrazAustria