memo - Magazine of European Medical Oncology

, Volume 2, Issue 4, pp 234–245

Imperative of continual support by the European Community for future advances in paediatric oncology in Europe: meeting report of the EC-funded science-communication project DIRECT “Overcoming Cancer with Research”

  • G. Tallen
  • M. Dworzak
  • H. Gadner
  • G. Masera
  • M. Schrappe
  • A. Biondi
  • G. Vassal
  • R. Pieters
  • J. Jazbec
  • B. Morland
  • Ursula Creutzig
Experts Statement

DOI: 10.1007/s12254-009-0168-9

Cite this article as:
Tallen, G., Dworzak, M., Gadner, H. et al. memo (2009) 2: 234. doi:10.1007/s12254-009-0168-9

Background/Purpose

Remarkable advances in paediatric cancer research and treatment were achieved during the last decades: In industrialised nations, overall cure rates were raised from below 20% to over 75% during the last forty years. Randomised investigator-driven clinical trials have been the backbone of this progress so far. The EU Clinical Trial Directive was introduced to improve the quality and safety of drug development; however, it has created considerable administrative “extra” workload as well as financial constraints for trials aiming at cancer treatment optimisation in children. It failed to provide harmonisation for clinical trials throughout Europe because translation into national law was highly divergent. To address the resulting challenges for future advances in European paediatric oncology including the promotion of new drug development, improved communication between all stakeholders is warranted.

Methods

Supported by the EC-funded FP7 science-communication project “DIRECT”, a meeting of European paediatric oncologists, representatives of patients’ and parents’ associations, survivors, and competent authorities was organised to investigate past successes and future challenges in paediatric oncology in Europe.

Results

The DIRECT-Symposium contributed to assess what is required in the future to advance the care and closer approach to “total cure” of European children and adolescents with cancer in all medical, psychological and social aspects. Various strategies were discussed and are summarised in this article.

Conclusion

EC-funded science-communication projects such as DIRECT are successful means to foster the public awareness of the necessities in caring for and curing paediatric cancer patients in the future. Amongst these, appreciation of the specific conditions and a need of continual funding by the EU are imperative.

Keywords

Paediatric cancer research europe European commission FP7 clinical trials directive clinical trials therapy optimisation studies overcoming cancer with research/forschen heilt krebs/DIRECT 

Abbreviations

ALL

Acute lymphoblastic leukaemia

CTD

Clinical trials directive

DIRECT

Disseminate Results from EC funded projects improved Therapy options in paediatric oncology

EC

European commission

EMEA

European medicine agency

EORTC

European organisation for research and treatment of cancer

EU

European union

FP7

7th Framework programme

GCP

Good clinical practice

GPOH

Society of paediatric oncology/haematology

IARC

International agency for research on cancer

I–BFM

International Berlin/Frankfurt/Muenster study group

IDCT

Investigator driven clinical trials

IMP

Investigational medicinal product

ITCC

European consortium for innovative therapies for children with cancer

KPOH

German competent net for paediatric oncology/ haematology

PDCO

Paediatric committee

PIP

Paediatric investigation plan

SIOP (-E)

International society of paediatric oncology (-Europe)

TOS

Therapy optimising study

Copyright information

© Springer 2009

Authors and Affiliations

  • G. Tallen
    • 1
    • 11
  • M. Dworzak
    • 2
    • 3
  • H. Gadner
    • 2
    • 3
  • G. Masera
    • 4
  • M. Schrappe
    • 5
  • A. Biondi
    • 4
    • 6
  • G. Vassal
    • 7
  • R. Pieters
    • 8
  • J. Jazbec
    • 9
  • B. Morland
    • 10
  • Ursula Creutzig
    • 11
  1. 1.Deptartment of Paediatric Oncology/Haematology, CharitéUniversitätsmedizin-BerlinBerlinGermany
  2. 2.St. Anna Children’s HospitalViennaAustria
  3. 3.Children’s Cancer Research InstituteViennaAustria
  4. 4.Deptartment of PaediatricsUniversity of Milano-Bicocca, San Gerardo HospitalMonzaItaly
  5. 5.Deptartment of PaediatricsUniversity of Schleswig-HolsteinKielGermany
  6. 6.Tettamanti Research Centre, San Gerardo HospitalUniversity of Milano-BicoccaMonzaItaly
  7. 7.Clinical and Translational Research, Institute Gustave-RoussyUniversity Paris-SudVillejuif CedexFrance
  8. 8.Erasmus MC – Sophia Children’s HospitalRotterdamThe Netherlands
  9. 9.Deptartment of Paediatric OncologyMedical University of LjubljanaLjubljanaSlovenia
  10. 10.Birmingham Children’s HospitalBirminghamUK
  11. 11.Competence Network Paediatric Oncology and Haematology (KPOH), Department of Paediatric Haematology/OncologyWestfaelische Wilhelms-University MünsterMünsterGermany