Case report

memo - Magazine of European Medical Oncology

, Volume 1, Issue 1, pp 39-41

First online:

Complete cytogenetic remission in a patient with FIP1L1-PDGFRA fusion negative chronic eosinophilic leukemia associated with atypical thrombotic events

  • A. ZaberniggAffiliated withDepartment of Internal Medicine and Oncology, General Hospital Kufstein Email author 
  • , M. ErdelAffiliated withDepartment of Medical Genetics, Molecular and Clinical Pharmacology, University Innsbruck
  • , R. SchranzhoferAffiliated withDepartment of Internal Medicine and Oncology, General Hospital Kufstein
  • , K. BerekAffiliated withDepartment of Neurology, General Hospital Kufstein
  • , K. GattringerAffiliated withDepartment of Internal Medicine and Oncology, General Hospital Kufstein

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Summary

We present a rare case of a patient with chronic eosinophilic leukemia, who did not develope the well known organ involvements of the heart, lungs, the skin or nervous system, but who suffered form atypical thrombotic complications including a life threatening sinovenous thrombosis. His disease showed a rapid response to a very low dose of imatinib an the complete remission of a complex cytogenetic abnormality.

Keywords

Hypereosinophilic syndrome Chronich eosinophilic leukemia Thrombosis Imatinib