Pathology & Oncology Research

, Volume 19, Issue 4, pp 731–737

Collagen Triple Helix Repeat Containing-1 (CTHRC1) Expression in Invasive Ductal Carcinoma of the Breast: The Impact on Prognosis and Correlation to Clinicopathologic Features

Authors

  • Joo Heon Kim
    • Department of PathologyEulji University School of Medicine
  • Tae-Hwa Baek
    • Department of PathologyEulji University School of Medicine
  • Hyun Sun Yim
    • Department of PathologyEulji University School of Medicine
  • Kyo Hyun Kim
    • Preventive MedicineEulji University School of Medicine
  • Seong-Hoo Jeong
    • Department of Surgery, Medical SchoolChonbuk National University
  • Ho Bum Kang
    • Medical Genomics Research CenterKorea Research Institute of Bioscience and Biotechnology
  • Sang-seok Oh
    • Division of Applied Life Science (BK21), PMBBRCGyeongsang National University, 501 Jinju-daero
  • Hee Gu Lee
    • Medical Genomics Research CenterKorea Research Institute of Bioscience and Biotechnology
  • Jae Wha Kim
    • Medical Genomics Research CenterKorea Research Institute of Bioscience and Biotechnology
    • Division of Applied Life Science (BK21), PMBBRCGyeongsang National University, 501 Jinju-daero
Research

DOI: 10.1007/s12253-013-9636-y

Cite this article as:
Kim, J.H., Baek, T., Yim, H.S. et al. Pathol. Oncol. Res. (2013) 19: 731. doi:10.1007/s12253-013-9636-y

Abstract

CTHRC1 has been known as a regulator of collagen expression and cell migration. The aim of this research was to clarify the clinicopathologic significance of CTHRC1 expression in human breast cancer. 22 cases of breast cancer tissues, randomly selected from clinically diagnosed patients, showed a significant increase of CTHRC1 mRNA expression compared to the normal tissue from the same patients using RT-PCR and real-time PCR. Additionally we investigated breast cancers from 189 patients by immunohistochemistry (IHC). A high level of CTHRC1 expression was observed in 111 (58.7 %) out of 189 breast cancer patients and the expression was significantly correlated with histologic grade (P = 0.026), nodal status (P < 0.001), and TNM pathologic stage (P = 0.002). High CTHRC1 expression was associated with a shorter recurrence free survival (P = 0.008). Taken together, the results showed that CTHRC1 over-expression was significantly associated with clinicopathological factors of poor prognosis in invasive ductal carcinoma. CTHRC1 could be used as a supplementary prognostic biomarker and a potential therapeutic target in breast cancer.

Keywords

CTHRC1 Immunohistochemistry Metastasis Breast cancer

Copyright information

© Arányi Lajos Foundation 2013