, Volume 18, Issue 3, pp 737-741
Date: 30 Nov 2011

Uncommon Late Relapse of Angioimmunoblastic T-Cell Lymphoma after 16-Year Remission Period

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Angioimmunoblastic T-cell lymphoma is rare and aggressive disorder representing approximately 2% of all non-Hodgkin lyphomas [1], that affects mainly elderly patients [2]. Allergic reactions, infections and chemicals can all play role in the etiology [3], in most of the cases EBV genome can be detected in the environmental B-cells [46]. It is suggested that the EBV-related B-cell proliferation is secondary effect due to immunosupression [7].

Most patients present with fever, weight loss, lymphadenopathy, splenomegaly and skin rushes. Laboratory findings may include anaemia (often autoimmune hemolytic type), thrombocytopenia, elevated level of LDH and polyclonal hypergammaglobulinaemia [2]. Nevertheless, several autoimmune phenomena have been reported in association with AITL [815]. Characteristic histological features are effaced nodal architecture, increased vascular proliferation, dilated sinuses, and polymorphous T-cell infiltration with plasmacytes, macrophages, eosino