Pathology & Oncology Research

, Volume 17, Issue 2, pp 415–420

Well-Differentiated Liposarcoma of the Oesophagus: Clinicopathological, Immunohistochemical and Array CGH Analysis

  • Jae Kyung Myung
  • Ji Bong Jeong
  • Daehee Han
  • Chi Sung Song
  • Hyeon Jong Moon
  • Young A. Kim
  • Ji Eun Kim
  • Sun-ju Byun
  • Woo Ho Kim
  • Mee Soo Chang
Case Report

DOI: 10.1007/s12253-010-9322-2

Cite this article as:
Myung, J.K., Jeong, J.B., Han, D. et al. Pathol. Oncol. Res. (2011) 17: 415. doi:10.1007/s12253-010-9322-2

Abstract

Liposarcoma develops extremely rarely in the oesophagus. Microscopically, it exhibits subtle atypia of H&E-stained features. Accordingly, immunohistochemical features and chromosomal alterations are used for its confirmatory diagnosis. However, cytogenetic analysis has not been performed for oesophageal liposarcoma. We studied chromosomal alterations using array comparative genomic hybridization (CGH), as well as endoscopic, radiological, H&E-stained and immunohistochemical features in the oesophageal well-differentiated liposarcoma of a 67-year-old man. Array CGH analysis revealed the presence of high-level amplifications at chromosomal locations 1p12–1q21.2, 12q13.2–12q15 and 12q21.33–12q23.1. At least 29 genes were highly amplified (log2 ratio >2), among which CDK4 and MDM2 were the most highly amplified (log2 ratio >4) and were accepted as major target genes. Moreover, the amplification of AMDHD1, HAL and LTA4H (log2 ratio = 3.153) was a novel finding. This case suggests the presence of a characteristic profile of gene amplification in well-differentiated liposarcoma of the oesophagus. The amplified genes may be of pathogenic importance for primary oesophageal well-differentiated liposarcoma.

Keywords

OesophagusWell-differentiated liposarcomaArray comparative genomic hybridizationChromosomeCDK4MDM2

Copyright information

© Arányi Lajos Foundation 2010

Authors and Affiliations

  • Jae Kyung Myung
    • 1
    • 2
  • Ji Bong Jeong
    • 3
  • Daehee Han
    • 4
  • Chi Sung Song
    • 5
  • Hyeon Jong Moon
    • 6
  • Young A. Kim
    • 1
    • 2
  • Ji Eun Kim
    • 1
    • 2
  • Sun-ju Byun
    • 1
    • 2
  • Woo Ho Kim
    • 2
  • Mee Soo Chang
    • 1
    • 2
  1. 1.Department of Pathology, Seoul National University Boramae HospitalSeoul National University College of MedicineSeoulKorea
  2. 2.Department of PathologySeoul National University College of MedicineSeoulKorea
  3. 3.Department of Internal MedicineSeoul National University Boramae HospitalSeoulKorea
  4. 4.Department of RadiologyCatholic University Seoul St. Mary’s HospitalSeoulKorea
  5. 5.Department of RadiologySeoul National University Boramae HospitalSeoulKorea
  6. 6.Department of Thoracic SurgerySeoul National University Boramae HospitalSeoulKorea