Pathology & Oncology Research

, Volume 17, Issue 1, pp 61–66

Glucose Transporter-1 (GLUT-1) Immunoreactivity in Benign, Premalignant and Malignant Lesions of the Gallbladder

  • Mateja Legan
  • Špela Tevžič
  • Ana Tolar
  • Boštjan Luzar
  • Vera Ferlan Marolt
Article

DOI: 10.1007/s12253-010-9281-7

Cite this article as:
Legan, M., Tevžič, Š., Tolar, A. et al. Pathol. Oncol. Res. (2011) 17: 61. doi:10.1007/s12253-010-9281-7

Abstract

GLUT-1 is a transmembrane glucose transport protein that allows the facilitated transport of glucose into cells, normally expressed in tissues which depend mainly on glucose metabolism. Enhanced expression of GLUT-1 can also be found in a large spectrum of carcinomas. This study aimed to investigate GLUT-1 expression in gallbladder tissue: from normal tissue samples, hyperplasias, low-grade and high-grade dysplasias to gallbladder carcinomas. In all, 115 archived samples of gallbladder tissue from 68 patients, presented after cholecystectomy, were immunohistochemically stained for GLUT-1. According to the intensity of GLUT-1 immunoreactivity, samples were divided into negative (stained 0–10% of cells stained), positive with weak to moderate (10–50%) and positive with strong (>50%) GLUT-1 expression. The GLUT-1 immunoreactivity of the samples showed a characteristic increase from premalignant lesions to carcinomas. Normal gallbladder tissue samples did not express GLUT-1 (100%). Weak expression was shown only focally in hyperplasias, but to a greater extent with low-grade dysplasias (20%), high-grade dysplasias (40%) and carcinomas (51.8%). Normal gallbladder tissue is GLUT-1 negative. GLUT-1 expression in carcinoma tissue is significantly higher than in dysplastic lesions. Strong GLUT-1 expression indicates 100% specificity for detecting gallbladder carcinomas. Therefore, GLUT-1 is a candidate as a diagnostic as well as a tissue prognostic marker in gallbladder carcinoma patients.

Keywords

Diagnosis Gallbladder adenocarcinoma GLUT-1 Immunohistochemistry Prognosis 

Abbrevations

GLUT-1

glucose transporter-1

No.

number

vs.

versus

Copyright information

© Arányi Lajos Foundation 2010

Authors and Affiliations

  • Mateja Legan
    • 1
  • Špela Tevžič
    • 1
  • Ana Tolar
    • 1
  • Boštjan Luzar
    • 2
  • Vera Ferlan Marolt
    • 2
  1. 1.Institute of Histology and EmbryologyFaculty of Medicine, University of LjubljanaLjubljanaSlovenia
  2. 2.Institute of PathologyFaculty of Medicine, University of LjubljanaLjubljanaSlovenia