Pathology & Oncology Research

, 15:495

Overexpression of Caveolin-1 in Hepatocellular Carcinoma with Metastasis and Worse Prognosis: Correlation with Vascular Endothelial Growth Factor, Microvessel Density and Unpaired Artery

  • Zhi-Bo Zhang
  • Lei Cai
  • Shu-Guo Zheng
  • Yan Xiong
  • Jia-Hong Dong
Original Paper

DOI: 10.1007/s12253-008-9144-7

Cite this article as:
Zhang, ZB., Cai, L., Zheng, SG. et al. Pathol. Oncol. Res. (2009) 15: 495. doi:10.1007/s12253-008-9144-7
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Abstract

Caveolin-1 is the major structural protein in caveolae, implicated in oncogenesis and angiogenesis. The connections between caveolin-1 and progression and angiogenesis of hepatocellular carcinoma (HCC) is still not clear. Thus we investigated the relationship of caveolin-1 expression, vascular endothelial growth factor (VEGF) expression, microvessel density (MVD), and unpaired artery (UA) with the clinicopathologic features of patients with HCC. Formalin-fixed, paraffin-embedded tissue sections of HCC from 75 patients who had undergone an initial hepatectomy were stained immunohistochemically with specific antibodies against caveolin-1, VEGF, CD34 and α-SMA. The levels of caveolin-1, VEGF, MVD and UA were correlated with the clinicopathologic variables, and tissue sections were also analyzed by dual-label immunofluorescence. We found that increased expression of caveolin-1 was associated with metastasis and with a worse prognosis of HCC. Caveolin-1 expression correlates positively with VEGF, MVD and UA. These results suggest that caveolin-1 may play an important role in the progression of HCC and angiogenesis.

Keywords

Caveolin-1 Vascular endothelial growth factor Angiogenesis Metastasis Prognosis Hepatocellular carcinoma Microvessel density Unpaired artery 

Abbreviations

HCC

hepatocellular carcinoma

MVD

microvessel density

UA

unpaired artery

VEGF

vascular endothelial growth factor

α-SMA

alpha smooth muscle actin

SECs

sinusoidal endothelial cells

MDN

macroregenerative and dysplastic nodules

Copyright information

© Arányi Lajos Foundation 2009

Authors and Affiliations

  • Zhi-Bo Zhang
    • 1
    • 2
  • Lei Cai
    • 1
  • Shu-Guo Zheng
    • 1
  • Yan Xiong
    • 1
  • Jia-Hong Dong
    • 1
  1. 1.Institute of Hepatobiliary Surgery & Southwest HospitalThird Military Medical UniversityChongqingPeople’s Republic of China
  2. 2.Department of Hepatopancreatobiliary Surgery, The First Affiliated HospitalFujian Medical UniversityFuzhouPeople’s Republic of China

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