Original Paper

Pathology & Oncology Research

, 15:473

First online:

Expression of EphA2 and E-cadherin in Gastric Cancer: Correlated with Tumor Progression and Lymphogenous Metastasis

  • Weijie YuanAffiliated withDepartment of General Surgery, Xiangya Hospital, Central South University
  • , Zhikang ChenAffiliated withDepartment of General Surgery, Xiangya Hospital, Central South University
  • , Shaobin WuAffiliated withDepartment of General Surgery, Xiangya Hospital, Central South University
  • , Jie GeAffiliated withDepartment of General Surgery, Xiangya Hospital, Central South University
  • , Shi ChangAffiliated withDepartment of General Surgery, Xiangya Hospital, Central South University
  • , Xianwei WangAffiliated withDepartment of General Surgery, Xiangya Hospital, Central South University
  • , Jingxiang ChenAffiliated withDepartment of General Surgery, Xiangya Hospital, Central South University
  • , Zihua ChenAffiliated withDepartment of General Surgery, Xiangya Hospital, Central South University Email author 

Rent the article at a discount

Rent now

* Final gross prices may vary according to local VAT.

Get Access

Abstract

In this study, gastric cancer progression was correlated with the over-expression of erythropoietin-producing hepatocellular (Eph)A2 receptor and down-expression of epithelial cadherin (E-cadherin). Immunohistochemistry of EphA2 and E-cadherin were performed on these tumor samples from 165 primary lesions of gastric cancer. The results showed that expression of EphA2 was obviously increased in gastric cancer tissues (P < 0.01), which was positively correlated with the depth of cancer invasion, tumor-node-metastasis (TNM) stage and lymph node metastasis (P < 0.05). Meanwhile, the expression of E-cadherin was significantly reduced (P < 0.01), which was negatively correlated with the depth of cancer invasion, grade of tumor differentiation, TNM stage and lymph node metastasis (P < 0.05). The correlation between EphA2 and E-cadherin expression was negative (r = −0.198, P = 0.011). In conclusion, either the over-expression of EphA2 or the down-expression of E-cadherin is correlated with cancer progression and lymphogenous metastasis in gastric cancer, suggesting that both of them may play an important role in tumor progression and metastasis.

Keywords

EphA2 E-cadherin Gastric cancer Immunohistochemistry