Pathology & Oncology Research

, Volume 15, Issue 2, pp 285–289

MALT Type Lymphoma Demonstrating Prominent Plasma Cell Differentiation Resembling Fibrous Variant of Hashimoto’s Thyroiditis: a Three Case Report

  • Masaru Kojima
  • Naoya Nakamura
  • Kazuhiko Shimizu
  • Atsuki Segawa
  • Sadayuki Kaba
  • Nobuhide Masawa
Original Paper

DOI: 10.1007/s12253-008-9108-y

Cite this article as:
Kojima, M., Nakamura, N., Shimizu, K. et al. Pathol. Oncol. Res. (2009) 15: 285. doi:10.1007/s12253-008-9108-y

Abstract

Fibrous variant of Hashimoto’s thyroiditis (HT) is characterized by marked fibrous replacement of one third or more of the thyroid parenchyma. We present here three cases of mucosa associated lymphoid tissue (MALT) type lymphoma demonstrating prominent plasma cell differentiation resembling fibrous variant of HT. Histologically, thyroid structures were disturbed by a diffuse and focally nodular infiltration by mature plasma cells and cells with plasma cell differentiation against a background of prominent hyalinosis. In addition, scattered centrocyte-like (CCL) cells and lymphoepithelial lesions were observed in all three lesions. A portion of the resected specimens in all three cases exhibited HT. However, immunohistochemical study demonstrated that the plasma cells and CCL-cells of these three lesions had monotypic intracytoplasmic kappa light chain. Moreover, these three lesions demonstrated a clonal band on polymerase chain reaction assay for the immunoglobulin heavy chain gene. To avoid underdiagnosis, we emphasize that careful attention should be paid to these immunological features as well as to morphological findings.

Keywords

MALT type lymphomaThyroid glandFibrous variantHashimoto’s thyroiditisImmunohistochemistry

Copyright information

© Arányi Lajos Foundation 2008

Authors and Affiliations

  • Masaru Kojima
    • 1
  • Naoya Nakamura
    • 2
  • Kazuhiko Shimizu
    • 3
  • Atsuki Segawa
    • 4
  • Sadayuki Kaba
    • 5
  • Nobuhide Masawa
    • 4
  1. 1.Department of Pathology and Clinical LaboratoriesGunma Cancer Center HospitalOhtaJapan
  2. 2.Department of PathologyTokai University School of MedicineIseharaJapan
  3. 3.Department of Pathology and Clinical LaboratoriesAshikaga Red Cross HospitalAshikagaJapan
  4. 4.Department of PathologyDokkyo University School of MedicineMibuJapan
  5. 5.Department of Laboratory Science, School of Health Science, Faculty of MedicineGunma UniversityMaebashiJapan