Original Paper

Pathology & Oncology Research

, Volume 14, Issue 1, pp 79-83

The Diagnostic Value of Macrophage Migration Inhibitory Factor (MIF) in Gastric Cancer

  • Hakan CamlicaAffiliated withPreventive Oncology, Biostatistics and Epidemiology, Institute of Oncology, University of Istanbul Email author 
  • , Derya DuranyildizAffiliated withBasic Oncology, Institute of Oncology, University of Istanbul
  • , Hilal OguzAffiliated withBasic Oncology, Institute of Oncology, University of Istanbul
  • , Ethem Nezih OralAffiliated withRadiation Oncology, Institute of Oncology, University of Istanbul
  • , Vildan YasaseverAffiliated withBasic Oncology, Institute of Oncology, University of Istanbul

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Abstract

The present study was conducted to investigate the sensitivity, specificity, predictive values and accuracy of serum MIF, CEA, CA 19-9 levels and their various combinations in patients with gastric cancer. Study group consists of pathologically verified, gastric cancer (n = 63) and apparently healthy controls (n = 50). Serum MIF concentrations were determined by enzyme-linked immunosorbent assay (ELISA). Serum values of patients were significantly higher than the controls (p = 0.011). Diagnostic sensitivity and specificity, predictive values and accuracies were calculated for each marker and their various combinations. The best results were achieved with the marker combination of MIF–CEA–CA 19-9 and MIF–CEA combination. In our opinion, the combination of the markers MIF–CEA is a valuable diagnostic tool for gastric cancer.

Keywords

MIF CEA CA 19-9 Tumor markers Gastric cancer Accuracy