Virologica Sinica

, Volume 27, Issue 3, pp 145–153

Developments of subunit and VLP vaccines against influenza a virus


DOI: 10.1007/s12250-012-3241-1

Cite this article as:
Deng, M., Hu, Z., Wang, H. et al. Virol. Sin. (2012) 27: 145. doi:10.1007/s12250-012-3241-1


Influenza virus is a continuous and severe global threat to mankind. The continuously re-emerging disease gives rise to thousands of deaths and enormous economic losses each year, which emphasizes the urgency and necessity to develop high-quality influenza vaccines in a safer, more efficient and economic way. The influenza subunit and VLP vaccines, taking the advantage of recombinant DNA technologies and expression system platforms, can be produced in such an ideal way. This review summarized the recent advancements in the research and development of influenza subunit and VLP vaccines based on the recombinant expression of hemagglutinin antigen (HA), neuraminidase antigen (NA), Matrix 2 protein (M2) and nucleocapsid protein (NP). It would help to get insight into the current stage of influenza vaccines, and suggest the future design and development of novel influenza vaccines.

Key words

InfluenzaSubunit vaccineVLPRecombinant expression

Copyright information

© Wuhan Institute of Virology, CAS and Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  • Ma-ping Deng
    • 1
  • Zhi-hong Hu
    • 1
  • Hua-lin Wang
    • 1
  • Fei Deng
    • 1
  1. 1.State Key Laboratory of Virology and Joint-Lab of Invertebrate Virology, Chinese Virus Resource and Bioinformatics Center, Wuhan Institute of VirologyChinese Academy of SciencesWuhanChina