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Current status of natural products from plants as anti-herpes simplex virus 1 agents

  • Published:
Virologica Sinica

Abstract

Nucleoside analogues have been the mainstay of clinical treatment of herpes simplex virus 1 (HSV-1) infections since their development. However, the emergence of drug resistant strains has underlined the urgency of the discovery of novel anti-HSV-1 drugs. Natural products, which provided many novel drug leads, are known to be an important source of anti-HSV-1 agents. Herein, we present an overview of natural products with anti-HSV-1 activities isolated from a variety of plants reported in recent years. Several different compounds, mainly belonging to the three groups of polysaccharides, polyphenols and terpenes, showed antiviral effects against HSV-1, indicating their potential to be promising anti-HSV-1 agents.

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Authors and Affiliations

  1. Biomedicine Research & Development Center, Jinan University, Guangzhou, 510630, China

    Yang-fei Xiang, Ying Pei & Yi-fei Wang

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  1. Yang-fei Xiang
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  2. Ying Pei
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Correspondence to Yi-fei Wang.

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Foundation item: Joint funds of National Natural Science Foundation of China (U0632010)

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Xiang, Yf., Pei, Y. & Wang, Yf. Current status of natural products from plants as anti-herpes simplex virus 1 agents. Virol. Sin. 23, 305–314 (2008). https://doi.org/10.1007/s12250-008-2962-7

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  • DOI: https://doi.org/10.1007/s12250-008-2962-7

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