Journal of Pharmaceutical Innovation

, Volume 8, Issue 4, pp 212–217

Oxybenzone Entrapped in Mesoporous Silicate MCM-41

  • Valeria Ambrogi
  • Loredana Latterini
  • Fabio Marmottini
  • Maria Cristina Tiralti
  • Maurizio Ricci
Research Article

DOI: 10.1007/s12247-013-9161-2

Cite this article as:
Ambrogi, V., Latterini, L., Marmottini, F. et al. J Pharm Innov (2013) 8: 212. doi:10.1007/s12247-013-9161-2

Abstract

Purpose

Oxybenzone is an organic ultraviolet absorbent commonly used as photoprotection agent in cosmetic formulations. Unfortunately, it shows safety problems because of its potential systemic absorption and skin photosensibilization. Thus, a new particulate carrier is proposed with the aim of solving these problems.

Methods

Oxybenzone (OXY) was loaded into the mesopores of the silicate MCM-41 and the obtained particulate carrier (MCM-41-OXY) was mixed with melt tristearin or stearyl alcohol with the aim of plugging the MCM-41 mesopores and thus entrapped OXY inside the pores. These particles were characterized and incorporated in an emulgel. OXY release from these formulations was evaluated in vitro and was compared with those from emulgels containing free OXY and unplugged MCM-41-OXY. The photoprotection range of the hybrid materials was also investigated through spectrophotometric measurements.

Results

As concerns with UV absorption properties, it can be observed that the spectrum of the neat compound appears broader than those recorded for lipid/silicate particles and MCM-41-OXY, but MCM-41-OXY with tristearin presents a higher absorption intensity in UVA, UVB, and UVC regions, maintaining thus excellent photoprotection effects. Besides this aspect, the pore occlusion by means of the lipid ingredients offers a proper obstacle to sunscreen release, thus preventing the contact between the sunscreen and the skin and consequently both systemic absorption and cutaneous adverse reactions.

Conclusions

The new lipid/MCM-41 particles appear to be promising candidates to formulate sunscreen preparations.

https://static-content.springer.com/image/art%3A10.1007%2Fs12247-013-9161-2/MediaObjects/12247_2013_9161_Figa_HTML.gif
Figure

Absorption spectra of neat OXY (black line) (a), MCM-41-OXY (red line) (b), MCM-41-OXYSTE (blue line) (c) and MCM-41-OXY- TRI (green line) (d) (on the left) and in vitro release profiles of OXY from neat OXY (a) and MCM-41-OXY (b) emulgels (on the right).

Keywords

Ordered mesoporous silicateUltraviolet absorbentSunscreen releasePhotoprotection

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Valeria Ambrogi
    • 1
  • Loredana Latterini
    • 2
  • Fabio Marmottini
    • 3
  • Maria Cristina Tiralti
    • 1
  • Maurizio Ricci
    • 1
  1. 1.Dipartimento di Chimica e Tecnologia del FarmacoUniversità degli Studi di PerugiaPerugiaItaly
  2. 2.CEMIN-Dipartimento di ChimicaUniversità di PerugiaPerugiaItaly
  3. 3.Dipartimento di Ingegneria Civile ed AmbientalePerugiaItaly