Cell palpation with an optically trapped particle
We have developed a cell palpation system to investigate cell stiffness from the reaction force generated on a particle that is fixed on a cell. In this method, a particle is used as a probe, and is manipulated towards a cell using optical tweezers. Using this method, we can obtain information of local stiffness of a cell. We investigate focal adhesion formation of a cell probed by a particle and we report different particle coating utilized for attaching certain protein in cell membrane. Also we discuss the effects of endocytosis.
- Cell palpation with an optically trapped particle
- Open Access
- Available under Open Access This content is freely available online to anyone, anywhere at any time.
Journal of Micro-Nano Mechatronics
Volume 7, Issue 4 , pp 131-136
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- Optical tweezers
- Cell stiffness
- Author Affiliations
- 1. Graduate School of Information Science, Nara Institute of Science and Technology, 8916-5 Takayama-cho, Ikoma, Nara, 630-0192, Japan
- 2. Faculty of Bioscience and Applied Chemistry, Housei University, 3-7-2 Kajino-machi, Koganei, Tokyo, 184-8584, Japan