Regular Article

Environmental Health and Preventive Medicine

, Volume 18, Issue 2, pp 104-109

First online:

Maternal and paternal family history of type 2 diabetes differently influence lipid parameters in young nondiabetic Japanese women

  • Kemal SasakiAffiliated withSagamihara Public Health CenterAichi Children’s Health and Medical Center Email author 
  • , Aya YoshidaAffiliated withSagamihara Public Health Center
  • , Hiroshi OhtaAffiliated withDepartment of Public Health, Kitasato University School of Medicine
  • , Yoshiharu AizawaAffiliated withDepartment of Preventive Medicine, Kitasato University School of Medicine
  • , Akiko KojimaAffiliated withSagamihara Public Health Center
  • , Hitomi ChibaAffiliated withSagamihara Public Health Center
  • , Shin MizuguchiAffiliated withSagamihara Public Health Center
  • , Tatsunori IshidzukaAffiliated withSagamihara Public Health Center
  • , Hiroshi GotoAffiliated withSagamihara Public Health Center
    • , Chiho UegakiAffiliated withSagamihara Public Health Center
    • , Kyuhei KotakeAffiliated withSagamihara Public Health Center

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We assessed the association of family history of type 2 diabetes (T2D) with parameters used for health checkups in young Japanese women.


The subjects were 497 nondiabetic women aged 19–39 years. Among them, the mothers of 34 subjects and fathers of 50 had T2D (MD group and PD group, respectively). The subjects were assessed for levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglyceride (TG).


TC and LDL-C level showed a tendency to increase in the MD group compared with subjects without family history of T2D. LDL-C/HDL-C ratio ≥2.14 was found in 32.4 and 18.0 % of subjects in the MD and PD groups, respectively. When adjusted for differences in age, body mass index, smoking status, and drinking habits, the MD group was found to have a higher risk of abnormal TC and LDL-C levels than the PD group. LDL-C/HDL-C ratio was independently associated with maternal family history but not with paternal family history (odds ratio 3.44 [99 % confidence interval 1.11–10.6] and 1.21 [0.38–3.89], respectively). There was no association between TG/HDL-C ratio and family history type of T2D.


Maternal family history of T2D had a more pronounced effect on the lipid parameters generally evaluated during health checkups than did paternal family history of T2D. Therefore, we recommend systematic screening for early detection and appropriate healthcare guidance for Japanese women, particularly those with maternal family history of T2D.


Diabetes Family history Dyslipidemia Low-density lipoprotein cholesterol/high-density lipoprotein cholesterol ratio Health checkup