Environmental Health and Preventive Medicine

, Volume 18, Issue 2, pp 104–109

Maternal and paternal family history of type 2 diabetes differently influence lipid parameters in young nondiabetic Japanese women

  • Kemal Sasaki
  • Aya Yoshida
  • Hiroshi Ohta
  • Yoshiharu Aizawa
  • Akiko Kojima
  • Hitomi Chiba
  • Shin Mizuguchi
  • Tatsunori Ishidzuka
  • Hiroshi Goto
  • Chiho Uegaki
  • Kyuhei Kotake
Regular Article

DOI: 10.1007/s12199-012-0296-4

Cite this article as:
Sasaki, K., Yoshida, A., Ohta, H. et al. Environ Health Prev Med (2013) 18: 104. doi:10.1007/s12199-012-0296-4

Abstract

Objectives

We assessed the association of family history of type 2 diabetes (T2D) with parameters used for health checkups in young Japanese women.

Methods

The subjects were 497 nondiabetic women aged 19–39 years. Among them, the mothers of 34 subjects and fathers of 50 had T2D (MD group and PD group, respectively). The subjects were assessed for levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglyceride (TG).

Results

TC and LDL-C level showed a tendency to increase in the MD group compared with subjects without family history of T2D. LDL-C/HDL-C ratio ≥2.14 was found in 32.4 and 18.0 % of subjects in the MD and PD groups, respectively. When adjusted for differences in age, body mass index, smoking status, and drinking habits, the MD group was found to have a higher risk of abnormal TC and LDL-C levels than the PD group. LDL-C/HDL-C ratio was independently associated with maternal family history but not with paternal family history (odds ratio 3.44 [99 % confidence interval 1.11–10.6] and 1.21 [0.38–3.89], respectively). There was no association between TG/HDL-C ratio and family history type of T2D.

Conclusions

Maternal family history of T2D had a more pronounced effect on the lipid parameters generally evaluated during health checkups than did paternal family history of T2D. Therefore, we recommend systematic screening for early detection and appropriate healthcare guidance for Japanese women, particularly those with maternal family history of T2D.

Keywords

DiabetesFamily historyDyslipidemiaLow-density lipoprotein cholesterol/high-density lipoprotein cholesterol ratioHealth checkup

Copyright information

© The Japanese Society for Hygiene 2012

Authors and Affiliations

  • Kemal Sasaki
    • 1
    • 4
  • Aya Yoshida
    • 1
  • Hiroshi Ohta
    • 2
  • Yoshiharu Aizawa
    • 3
  • Akiko Kojima
    • 1
  • Hitomi Chiba
    • 1
  • Shin Mizuguchi
    • 1
  • Tatsunori Ishidzuka
    • 1
  • Hiroshi Goto
    • 1
  • Chiho Uegaki
    • 1
  • Kyuhei Kotake
    • 1
  1. 1.Sagamihara Public Health CenterSagamiharaJapan
  2. 2.Department of Public HealthKitasato University School of MedicineSagamiharaJapan
  3. 3.Department of Preventive MedicineKitasato University School of MedicineSagamiharaJapan
  4. 4.Aichi Children’s Health and Medical CenterObuJapan