Evaluation of subjective symptoms of Japanese patients with multiple chemical sensitivity using QEESI©
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The Quick Environment Exposure Sensitivity Inventory (QEESI©) has been used as a questionnaire to evaluate subjective symptoms of patients with multiple chemical sensitivity (MCS), also known as idiopathic environmental intolerance, in Japan. However, no cutoff value for Japanese subjects has yet been established. We designed this study to establish a cutoff value for Japanese subjects using QEESI© for screening of MCS patients.
A questionnaire using the QEESI© was administered to 103 MCS patients and 309 healthy control subjects matched for age and sex. QEESI© scores of the two groups were compared using logistic regression analysis, receiver operating characteristic analysis, and the Mann–Whitney test.
Cutoff values for Japanese subjects were determined for the Chemical Intolerance subscale (40), Symptom Severity subscale (20), and Life Impact subscale (10). The subjects whose scores exceeded the cutoff values in any two subscales accounted for 88.4% of the patients but only 14.5% of the controls.
Our results suggest that subjects meeting two out of three subscale criteria can be screened as “patients suffering from a low level of environmental chemicals such as MCS” in Japan.
- Australian Government: A Scientific Review of Multiple Chemical Sensitivity: Identifying Key Research Needs; Working Draft Report prepared by the National Industrial Chemicals Notification and Assessment Scheme (NICNAS) and the Office of Chemical Safety (OCS), November 2008; p. 1–72. http://www.nicnas.gov.au/Current Issues/MCS ReportPDF.pdf.
- Ashford NA, Miller CS. Appendix C: environmental exposure and sensitivity inventory. In: Chemical exposure: low levels and high stakes. 2nd ed. New York: Wiley; 1998. p. 371–84.
- Bailer J, Rist F, Witthoft M, Paul C. Validation of a screening instrument by multiple chemical sensitivity (MCS): the chemical odor sensitivity scale (COSS). Psychother Psychosom Med Psychol. 2004;54(11):396–404. CrossRef
- Bailer J, Witthot M, Rist F. The Chemical Odor Sensitivity Scale: reliability and validity of screening instrument for idiopathic environmental intolerance. J Psychosom Res. 2006;61(1):71–9. CrossRef
- Bailer J, Witthoft M, Rist F. Psychological predictors of short- and medium term outcome in individuals with idiopathic environmental intolerance (EI) and individuals with somatoform disorder. J Toxicol Environ Health. 2008;71:766–75. CrossRef
- Bell IR, Miller CS, Schwartz GE. An olfactory-limbic model of multiple chemical sensitivity syndrome: possible relationships to kindling and affective spectrum disorders. Biol Psychiatry. 1992;32(3):218–42. CrossRef
- Caress SM, Steinemann AC. A review of a two-phase population study of multiple chemical sensitivities. Environ Health Perspect. 2003;111(12):1490–7.
- Cullen MR. The worker with multiple chemical sensitivities: an overview. Occup Med. 1987;2(4):655–61.
- Meggs WJ, Dunn KA, Bloch RM, Goodman PE, Davidoff AL. Prevalence and nature of allergy and chemical sensitivity in a general population. Arch Environ Health. 1996;51(4):275–82.
- Witthoft M, Rist F, Baller J. Abnormalities in cognitive- emotional processing in idiopathic environmental intolerance and somatoform disorders. J Behav Ther Exp Psychiatry. 2008; (Epub ahead of print).
- Randolff TG. Ecologic orientation in medicine: comprehensive environmental control in diagnosis and therapy. Ann Allergy. 1965;23:11–22.
- Cullen MR. The worker with multiple chemical sensitivities: an overview. Occup Med. 1987;2:655–61.
- Nethercott JR, Davidoff LL, Curbow B, Abbey H. Multiple chemical sensitivities syndrome: toward a working case definition. Arch Environ Health. 1993;48:19–26.
- Anonymous. Consensus on multiple chemical sensitivity. Multiple chemical sensitivity. Arch Environ Health. A 1999 consensus, 1999; 54(3):147–9.
- Lacour M, Zunder T, Schmidtke K, Vaith P, Scheidt C. Multiple chemical sensitivity syndrome (MCS)—suggestions for an extension of the U.S. MCS—case definition. Int J Hyg Environ Health. 2005;208:141–51. CrossRef
- Ishikawa S, Miyata M, Namba T, Nishimoto H. Diagnosis of chemical sensitivity. Jpn Med J. 1998;3857:25–9. (in Japanese).
- Miller CS, Prihoda TJ. The Environmental Exposure and Sensitivity Inventory (EESI): a standardized approach for measuring chemical intolerances for research and clinical applications. Toxicol Ind Health. 1999;15(3–4):370–85.
- Miller CS, Prihoda TJ. A controlled comparison of symptoms and chemical intolerances reported by Gulf War veterans, implant recipients, and persons with multiple chemical sensitivity. Toxicol Ind Health. 1999;15(3–4):386–97.
- Ishikawa S, Miyata M. Multiple chemical sensitivity: criteria and test methods for diagnosis (in Japanese). Allergol Immunol. 1999;6(7):990–8. (in Japanese).
- Hojo S, Kumano H, Yoshino H, Kakuta K, Ishikawa S. Application of Quick Environment Exposure Sensitivity Inventory (QEESI©) for Japanese population: study of reliability and validity of the questionnaire. Toxicol Ind Health. 2003;19(2–6):41–9. CrossRef
- Hojo S, Yoshino H, Kumano H, Kakuta K, Miyata M, Sakabe K, et al. Use of QEESI© questionnaire for a screening study in Japan. Toxicol Ind Health. 2005;21(5–6):113–24. CrossRef
- Hojo S, Kumano H, Ishikawa S, Miyata M, Sakabe K. Clinical characteristics of physician- diagnosed patients with multiple chemical sensitivity in Japan, Int. J Hyg Environ Health. 2008;211:682–9. CrossRef
- Hojo S, Ishikawa S, Kumano H, Miyata M, Mastui T, Sakabe K. Subjective and objective characteristics of patients with multiple chemical sensitivity in Japan. Jpn J Clin Ecol. 2007;16(2):104–16.
- Miller CS, Mitzel HC. Chemical sensitivity attributed to pesticide exposure versus remodeling. Arch Environ Health. 1995;50:119–29.
- Evaluation of subjective symptoms of Japanese patients with multiple chemical sensitivity using QEESI©
Environmental Health and Preventive Medicine
Volume 14, Issue 5 , pp 267-275
- Cover Date
- Print ISSN
- Online ISSN
- Springer Japan
- Additional Links
- Multiple chemical sensitivity (MCS)
- Idiopathic environmental intolerance (IEI)
- Quick Environment Exposure Sensitivity Inventory (QEESI©)
- Logistic regression analysis
- Receiver operating characteristics (ROC) analysis
- Author Affiliations
- 1. Department of Environmental Science, Shokei Gakuin University, 4-10-1 Yurigaoka, Natori, Miyagi, 981-1295, Japan
- 2. Department of Human Structure and Function, Tokai University School of Medicine, Kanagawa, Japan
- 3. Division of Environmental Medical Center, Kitasato Institute Hospital, Tokyo, Japan
- 4. Faculty of Human Sciences, Waseda University, Saitama, Japan