Bone Physiology, Biomaterial and the Effect of Mechanical/Physical Microenvironment on Mesenchymal Stem Cell Osteogenesis
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- Liao, X., Lu, S., Zhuo, Y. et al. Cel. Mol. Bioeng. (2011) 4: 579. doi:10.1007/s12195-011-0204-9
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In this review, we summarize the research progress in understanding the physiology of bone cells interacting with different mechanical/physical environments during bone tissue regeneration/repair. We first introduce the cellular composition of the bone tissue and the mechanism of the physiological bone regeneration/repair process. We then describe the properties and development of biomaterials for bone tissue engineering, followed by the highlighting of research progresses on the cellular response to mechanical environmental cues. Finally, several latest advancements in bone tissue regeneration and remaining challenges in the field are discussed for future research directions.