Radiological Physics and Technology

, Volume 1, Issue 2, pp 196–200

Customization of normal data base specific for 3-tesla MRI is mandatory in VSRAD analysis

  • Masami Goto
  • Yuuichi Suzuki
  • Osamu Abe
  • Naoto Hayashi
  • Shigeki Aoki
  • Harushi Mori
  • Tomohiko Masumoto
  • Yasushi Watanabe
  • Yoshirou Satake
  • Kenji Ino
  • Keiichi Yano
  • Kyouhito Iida
  • Kazuo Mima
  • Kuni Ohtomo
Article

DOI: 10.1007/s12194-008-0027-0

Cite this article as:
Goto, M., Suzuki, Y., Abe, O. et al. Radiol Phys Technol (2008) 1: 196. doi:10.1007/s12194-008-0027-0
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Abstract

A voxel-based specific regional analysis system for Alzheimer’s disease (VSRAD) was used for quantitative analysis of parahippocampal atropy with 1.5-tesla (T) MRI in a voxel-wise manner. The analysis of images acquired under a different imaging condition provides an error factor that has a calculated value. Clinical application of 3T-MRI is necessary for establishing a normal data base (N-DB) specific for 3T-MRI data, which permits appropriate application of VSRAD. We established an N-DB specific for 3T-MRI for use in VSRAD. The “Z-score of the parahippocampal gyrus” was 0.79 ± 0.32, and the N-DB of each age group did not have a big deflection when we analyzed a group of physically unimpaired persons in an N-DB specific for 3T-MRI. Therefore, we were able to confirm the validity of the customized N-DB. The “Z-score of the parahippocampal gyrus” was 1.62 ± 0.47 for the N-DB of VSRAD. The numerical value was high for the group of physically unimpaired persons.

Keywords

HippocampusCentral nervous systemMagnetic resonance imaging (MRI)Voxel-based morphometry (VBM)Alzheimer’s diseaseVoxel-based specific regional analysis system for Alzheimer’s disease (VSRAD)

Copyright information

© Japanese Society of Radiological Technology and Japan Society of Medical Physics 2008

Authors and Affiliations

  • Masami Goto
    • 1
  • Yuuichi Suzuki
    • 1
  • Osamu Abe
    • 2
  • Naoto Hayashi
    • 2
  • Shigeki Aoki
    • 2
  • Harushi Mori
    • 2
  • Tomohiko Masumoto
    • 2
  • Yasushi Watanabe
    • 1
  • Yoshirou Satake
    • 1
  • Kenji Ino
    • 1
  • Keiichi Yano
    • 1
  • Kyouhito Iida
    • 1
  • Kazuo Mima
    • 1
  • Kuni Ohtomo
    • 2
  1. 1.Department of Radiological TechnologyUniversity of Tokyo HospitalTokyoJapan
  2. 2.Department of RadiologyUniversity of Tokyo HospitalTokyoJapan