Date: 27 Nov 2007
Experimental verification of proton beam monitoring in a human body by use of activity image of positron-emitting nuclei generated by nuclear fragmentation reaction
Proton therapy is a form of radiotherapy that enables concentration of dose on a tumor by use of a scanned or modulated Bragg peak. Therefore, it is very important to evaluate the proton-irradiated volume accurately. The proton-irradiated volume can be confirmed by detection of pair-annihilation gamma rays from positron-emitting nuclei generated by the nuclear fragmentation reaction of the incident protons on target nuclei using a PET apparatus. The activity of the positron-emitting nuclei generated in a patient was measured with a PET-CT apparatus after proton beam irradiation of the patient. Activity measurement was performed in patients with tumors of the brain, head and neck, liver, lungs, and sacrum. The 3-D PET image obtained on the CT image showed the visual correspondence with the irradiation area of the proton beam. Moreover, it was confirmed that there were differences in the strength of activity from the PET-CT images obtained at each irradiation site. The values of activity obtained from both measurement and calculation based on the reaction cross section were compared, and it was confirmed that the intensity and the distribution of the activity changed with the start time of the PET imaging after proton beam irradiation. The clinical use of this information about the positron-emitting nuclei will be important for promoting proton treatment with higher accuracy in the future.
Chu WT, Ludewigt BA, Renner TR. Instrumentation for treatment of cancer using proton and light-ion beams. Rev Sci Instrum. 1993;64(8):2055–122.CrossRef
Bennett GW, Goldberg A, Levine G, Guthy J, Balsamo J. Beam localization via 15O activation in proton radiation therapy. Nucl Instr Meth. 1975;125:333–8.CrossRef
Nishio T, Ogino T, Shimbo M, Katsuta S, Kawasaki S, Murakami T, et al. Distributions of β+ decayed nucleus produced from the target fragment reaction in (CH2) n and patient liver targets by using a proton beam for therapy. Abstracts of the XXXIV PTCOG MEETING in Boston; 2001. pp. 15–6.
Hishikawa Y, Kagawa K, Murakami M, Sasaki H, Akagi T, Abe M. Usefulness of positron-emission tomographic images after proton therapy. Int J Rad Oncol Biol Phys. 2002;53:1388–91.CrossRef
Parodi K, Ponisch F, Enghardt W. Experimental study on the feasibility of in-beam PET for accurate monitoring of proton therapy. IEEE Trans Nucl Sci. 2005;52:778–86.CrossRef
Photon, Electron, Proton and Neutron Interaction Data for Body Tissues (ICRU Report 46). pp. 11–3.
Iljinov AS, Semenov VG, Semenova MP, Schopper H. Interactions of protons with nuclei (supplement to I/13a, b, c), (Landolt-Bornstein New Series. 1994).
Goldharber AS. Statistical models of fragmentation processes. Phys Lett. 1974;53B:306–8.
Winger A, Sherrill BM. Morrissey. INTENSITY: acomputer program for the estimation of secondary beam intensities from a projectile fragment separator. Nucl Instrum Methods. 1992;B70:380–92.
Nishio T. Proton therapy facility at National Cancer Center, Kashiwa, Japan. J At Energy Soc. 1999;41(11):1134–8.
Tachikawa T, Sato T, Ogino T, Nishio T. Proton treatment devices at National Cancer Center (Kashiwa). Radiat Indust. 1999;84:48–53.
Nishio T, Ogino T, Sakudo M, Tanizaki N, Yamada M, Nishida G, et al. Present proton treatment planning system at National Cancer Center Hospital East. Jpn J Med Phys Proc. 2000;20(Suppl. 4):174–7.
Boellaard R, Lingen AV, Lammertsma AA. Experimental and clinical evaluation of iterative reconstruction (OSEM) in dynamic PET: quantitative characteristics and effects on kinetic modeling. J Nucl Med. 2001;42:808–17.PubMed
- Experimental verification of proton beam monitoring in a human body by use of activity image of positron-emitting nuclei generated by nuclear fragmentation reaction
Radiological Physics and Technology
Volume 1, Issue 1 , pp 44-54
- Cover Date
- Print ISSN
- Online ISSN
- Additional Links
- Proton therapy
- Proton beam monitoring
- Beam OFF-LINE PET system
- PET-CT imaging
- Author Affiliations
- 1. Particle Therapy Division, Research Center for Innovative Oncology, National Cancer Center, Kashiwa, 6-5-1 Kashiwano-ha, Kashiwa-shi, Chiba, 277-8577, Japan
- 2. Department of Nuclear Engineering and Management, Graduate School of Engineering, University of Tokyo, 2-11-16 Yayoi, Bunkyo-ku, Tokyo, 113-0032, Japan
- 3. Department of Radiology, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan
- 4. Department of Radiology, National Cancer Center, Kashiwa, 6-5-1 Kashiwano-ha, Kashiwa-shi, Chiba, 277-8577, Japan
- 5. Functional Imaging Division, Research Center for Innovative Oncology, National Cancer Center, Kashiwa, 6-5-1 Kashiwano-ha, Kashiwa-shi, Chiba, 277-8577, Japan
- 6. Graduate School of Health Science, Tokyo Metropolitan University, 7-2-10 Higashiogu, Arakawa-ku, Tokyo, 116-8551, Japan