Cell Stress and Chaperones

, Volume 19, Issue 2, pp 281–287

AKR1B10 is induced by hyperglycaemia and lipopolysaccharide in patients with diabetic nephropathy

  • Nicholas Shaw
  • Bingmei Yang
  • Ann Millward
  • Andrew Demaine
  • Andrea Hodgkinson
Original Paper

DOI: 10.1007/s12192-013-0455-6

Cite this article as:
Shaw, N., Yang, B., Millward, A. et al. Cell Stress and Chaperones (2014) 19: 281. doi:10.1007/s12192-013-0455-6

Abstract

Aldose reductase family member B10 (AKR1B10) belongs to the aldo–keto reductase gene superfamily and is closely related to aldose reductase (AKR1B1). It has been shown that AKR1B10 is present in many of the same human tissues as AKR1B1. The objective of this study was to investigate whether AKR1B10 has a role in diabetic nephropathy (DN) by investigating its response to high glucose and inflammation, both of which have been associated with the development and progression of DN. Expression levels of AKR1B10 were determined in peripheral blood mononuclear cells (PBMCs) obtained from 25 patients with type 1 diabetes and nephropathy, 25 without DN and 25 normal healthy controls that were exposed to high glucose (25 mM d-glucose) and also the inflammatory stressor lipopolysaccharide (LPS, 10 μm). Under high glucose and LPS conditions, there was a significant increase in the expression of AKR1B10 in the PBMCs from patients with DN compared to those without DN and the normal controls. In conclusion, these results suggest that AKR1B10 may have an important role in the development and progression of DN.

Keywords

Aldose reductase family member B10Aldose reductaseDiabetic nephropathyHigh glucoseInflammationType 1 diabetes

Copyright information

© Cell Stress Society International 2013

Authors and Affiliations

  • Nicholas Shaw
    • 1
  • Bingmei Yang
    • 1
  • Ann Millward
    • 1
  • Andrew Demaine
    • 1
  • Andrea Hodgkinson
    • 1
  1. 1.Department of Molecular Medicine, Institute of Translational and Stratified MedicinePlymouth University Peninsula Schools of Medicine and DentistryPlymouthUK