Cell Stress and Chaperones

, Volume 17, Issue 2, pp 267–274

Prevention and treatment of alopecia areata with quercetin in the C3H/HeJ mouse model

  • Tongyu Cao Wikramanayake
  • Alexandra C. Villasante
  • Lucia M. Mauro
  • Carmen I. Perez
  • Lawrence A. Schachner
  • Joaquin J. Jimenez
Original Paper

DOI: 10.1007/s12192-011-0305-3

Cite this article as:
Wikramanayake, T.C., Villasante, A.C., Mauro, L.M. et al. Cell Stress and Chaperones (2012) 17: 267. doi:10.1007/s12192-011-0305-3

Abstract

Alopecia areata (AA) is an autoimmune non-scarring hair loss disorder. AA can be acute, recurrent, or chronic. Current therapeutic options for AA are limited, and there is no effective prevention for recurrent AA. We have previously shown a correlation between the expression of HSP70 (HSPA1A/B), a heat shock protein involved in the inflammatory response, and the onset of AA in the C3H/HeJ mouse model. In this study, we tested the effects of quercetin, a bioflavonoid with anti-inflammatory properties, on AA development and HSP70 expression in the C3H/HeJ model. Mice with spontaneous AA were treated with subcutaneous quercetin or sham injections. Hair regrowth was observed in lesional areas in all the quercetin-treated mice, but in none of the sham-treated mice. In addition, non-alopecic C3H/HeJ mice were heat-treated to induce alopecia, along with quercetin or sham injections. Whereas 24% of the heat-treated mice with sham injections developed alopecia, none of the mice receiving quercetin injections did. As expected, the level of HSP70 expression in quercetin-treated areas was comparable to control. Furthermore, we showed that systemic delivery of quercetin by intraperitoneal injections prevented/reduced spontaneous onset of AA. Our results demonstrated that quercetin provided effective treatment for AA as well as prevention of onset of AA in the C3H/HeJ model, and warrant further clinical studies to determine whether quercetin may provide both treatment for preexisting AA and prevention of recurrent AA. The ready availability of quercetin as a dietary supplement may lead to increased patient compliance and positive outcomes for AA.

Keywords

Alopecia areata C3H/HeJ HSP70 Heat shock Quercetin 

Abbreviations

AA

Alopecia areata

APC

Antigen-presenting cell

AT

Alopecia totalis

AU

Alopecia universalis

HF

Hair follicle

HSP

Heat shock protein

HSP70

Heat shock protein 70

IL-1, IL-2, IL-6, IL-10

Interleukins 1, 2, 6, 10

IFN-γ

Interferon-gamma

IGF-1

Insulin-like growth factor 1

IP

Immune privilege

α-MSH

Melanocyte-stimulating hormone

MHC

Major histocompatibility complex

NK

Natural killer

NF-κB

Nuclear factor kappa B

PUVA

Psoralen and ultraviolet A

TGF-β1

Transforming growth factor beta 1

TNF-α

Tumor necrosis factor alpha

Th1

T helper 1

Th2

T helper 2

Copyright information

© Cell Stress Society International 2011

Authors and Affiliations

  • Tongyu Cao Wikramanayake
    • 1
  • Alexandra C. Villasante
    • 1
  • Lucia M. Mauro
    • 1
  • Carmen I. Perez
    • 1
  • Lawrence A. Schachner
    • 1
  • Joaquin J. Jimenez
    • 1
  1. 1.Department of Dermatology and Cutaneous SurgeryUniversity of Miami Miller School of MedicineMiamiUSA

Personalised recommendations