Short Communication

Cell Stress and Chaperones

, Volume 14, Issue 1, pp 105-111

First online:

Guidelines for the nomenclature of the human heat shock proteins

  • Harm H. KampingaAffiliated withDepartment of Cell Biology, Section of Radiation and Stress Cell Biology, University Medical Center Groningen, University of Groningen Email author 
  • , Jurre HagemanAffiliated withDepartment of Cell Biology, Section of Radiation and Stress Cell Biology, University Medical Center Groningen, University of Groningen
  • , Michel J. VosAffiliated withDepartment of Cell Biology, Section of Radiation and Stress Cell Biology, University Medical Center Groningen, University of Groningen
  • , Hiroshi KubotaAffiliated withDepartment of Life Science, Faculty of Engineering and Resource Science, Akita UniversityDepartment of Molecular and Cellular Biology, Institute for Frontier Medical Sciences, Kyoto University
  • , Robert M. TanguayAffiliated withDepartment of Molecular and Cellular Biology, Institute for Frontier Medical Sciences, Kyoto UniversityLaboratory of Cellular and Developmental Genetics, Department of Medicine and CREFSIP, Université Laval
  • , Elspeth A. BrufordAffiliated withHUGO Gene Nomenclature Committee, European Bioinformatics Institute (EMBL–EBI)
  • , Michael E. CheethamAffiliated withUCL Institute of Ophthalmology
  • , Bin ChenAffiliated withInstitute of Entomology and Molecular Biology, College of Life Sciences, Chongqing Normal University
  • , Lawrence E. HightowerAffiliated withDepartment of Molecular and Cell Biology, University of Connecticut

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Abstract

The expanding number of members in the various human heat shock protein (HSP) families and the inconsistencies in their nomenclature have often led to confusion. Here, we propose new guidelines for the nomenclature of the human HSP families, HSPH (HSP110), HSPC (HSP90), HSPA (HSP70), DNAJ (HSP40), and HSPB (small HSP) as well as for the human chaperonin families HSPD/E (HSP60/HSP10) and CCT (TRiC). The nomenclature is based largely on the more consistent nomenclature assigned by the HUGO Gene Nomenclature Committee and used in the National Center of Biotechnology Information Entrez Gene database for the heat shock genes. In addition to this nomenclature, we provide a list of the human Entrez Gene IDs and the corresponding Entrez Gene IDs for the mouse orthologs.

Keywords

Nomenclature Human heat shock proteins