International Journal of Hematology

, Volume 99, Issue 4, pp 413–417

Eltrombopag therapy in newly diagnosed steroid non-responsive ITP patients

  • Anil Kumar Tripathi
  • Ayush Shukla
  • Sanjay Mishra
  • Yogendra Singh Yadav
  • Deependra Kumar Yadav
Original Article

DOI: 10.1007/s12185-014-1533-y

Cite this article as:
Tripathi, A.K., Shukla, A., Mishra, S. et al. Int J Hematol (2014) 99: 413. doi:10.1007/s12185-014-1533-y

Abstract

Primary immune thrombocytopenia (ITP) is an autoimmune disorder characterised by isolated thrombocytopenia (peripheral blood platelet count <100 × 109/L) in the absence of other causes or disorders that may be associated with thrombocytopenia. The upfront treatment in newly diagnosed ITP patients is steroids; however, about one-third patients do not respond, and require other treatment, including IVIg, anti-D, or splenectomy. Previous studies have shown decreased platelet production in some ITP patients, aside from the evidence of enhanced platelet destruction. Thrombopoietin receptor agonists (TPO-RA), such as eltrombopag have been shown to provide good response in steroid non-responsive chronic ITP patients. We have studied response to eltrombopag in 25 newly diagnosed steroid non-responsive ITP patients; 80 % patients showed response at the end of 1 month, and 76 % sustained response at the end of 3 months. The platelet count rose from a mean value of 17.5 ± 3.6–152.5 ± 107.9 × 109/L at the end of 1 month. Our results suggest a possible role of eltrombopag in newly diagnosed steroid non-responsive ITP patients. However, our study is limited in that it is a single-centre study, with a small sample size, and lacks a long-term safety profile. Our findings highlight the potential value of a larger prospective study on the upfront use of TPO-RA in patients of ITP.

Keywords

Primary ITPITPTPO-RAEltrombopag

Copyright information

© The Japanese Society of Hematology 2014

Authors and Affiliations

  • Anil Kumar Tripathi
    • 1
  • Ayush Shukla
    • 1
  • Sanjay Mishra
    • 1
  • Yogendra Singh Yadav
    • 1
  • Deependra Kumar Yadav
    • 1
  1. 1.Department of Clinical Hematology and Medical OncologyKing George’s Medical UniversityLucknowIndia