International Journal of Hematology

, Volume 97, Issue 4, pp 485–490

Feasibility of cord blood transplantation in chemosensitive adult T-cell leukemia/lymphoma: a retrospective analysis of the Nagasaki Transplantation Network

Authors

    • Department of Hematology, Atomic Bomb Disease and Hibakusha Medicine Unit, Atomic Bomb Disease InstituteNagasaki University Graduate School of Biomedical Sciences
    • Laboratory of Hematoimmunology, Department of Clinical Laboratory Sciences, Faculty of MedicineSchool of Health Sciences, University of the Ryukyus
  • Hidehiro Itonaga
    • Department of Hematology, Atomic Bomb Disease and Hibakusha Medicine Unit, Atomic Bomb Disease InstituteNagasaki University Graduate School of Biomedical Sciences
  • Yukiyoshi Moriuchi
    • Sasebo City General Hospital
  • Shinichiro Yoshida
    • National Hospital Organization Nagasaki Medical Center
  • Jun Taguchi
    • Department of Hematology, Atomic Bomb Disease and Hibakusha Medicine Unit, Atomic Bomb Disease InstituteNagasaki University Graduate School of Biomedical Sciences
  • Yoshitaka Imaizumi
    • Department of Hematology, Atomic Bomb Disease and Hibakusha Medicine Unit, Atomic Bomb Disease InstituteNagasaki University Graduate School of Biomedical Sciences
  • Daisuke Imanishi
    • Department of Hematology, Atomic Bomb Disease and Hibakusha Medicine Unit, Atomic Bomb Disease InstituteNagasaki University Graduate School of Biomedical Sciences
  • Hideki Tsushima
    • Department of Hematology, Atomic Bomb Disease and Hibakusha Medicine Unit, Atomic Bomb Disease InstituteNagasaki University Graduate School of Biomedical Sciences
  • Yasushi Sawayama
    • Department of Hematology, Atomic Bomb Disease and Hibakusha Medicine Unit, Atomic Bomb Disease InstituteNagasaki University Graduate School of Biomedical Sciences
  • Emi Matsuo
    • National Hospital Organization Nagasaki Medical Center
  • Tomoko Hata
    • Department of Hematology, Atomic Bomb Disease and Hibakusha Medicine Unit, Atomic Bomb Disease InstituteNagasaki University Graduate School of Biomedical Sciences
  • Yasushi Miyazaki
    • Department of Hematology, Atomic Bomb Disease and Hibakusha Medicine Unit, Atomic Bomb Disease InstituteNagasaki University Graduate School of Biomedical Sciences
Original Article

DOI: 10.1007/s12185-013-1307-y

Cite this article as:
Fukushima, T., Itonaga, H., Moriuchi, Y. et al. Int J Hematol (2013) 97: 485. doi:10.1007/s12185-013-1307-y

Abstract

It has been reported that cord blood transplantation (CBT) for patients with aggressive adult T-cell leukemia/lymphoma (ATL) results in poorer outcomes than transplantation using other stem cell sources. To identify a subset of ATL in which CBT is feasible, we retrospectively analyzed 27 patients treated with CBT at three institutions in Nagasaki Prefecture, Japan. The estimated overall survival (OS) rate at 3 years was 27.4 %. Of 16 patients who received CBT during remission (complete, CR, or partial, PR), the OS rate at 3 years was 50 %, while during refractory periods (non-CR or non-PR), the OS rate was 9.1 %. Reduced intensity conditioning (RIC) was given to 18 patients, and myeloablative conditioning (MAC) was used in nine, with 3-year OS of 50.0 and 0 %, respectively. Of the 19 deaths, nine were due to progressive disease, eight (five MAC and three RIC) to infection, and two to multiple organ failure. These results suggest that CBT provides similar results with those in other transplantation procedures for selected ATL patients, such as those in CR or PR. Further studies are needed to evaluate the use of CBT in aggressive ATL.

Keywords

Cord blood transplantationAdult T-cell leukemia/lymphomaChemosensitivity

Copyright information

© The Japanese Society of Hematology 2013