Primary testicular lymphoma: experience with 13 cases and literature review Authors
First Online: 25 January 2013 Received: 19 October 2012 Revised: 18 December 2012 Accepted: 27 December 2012 DOI:
Cite this article as: Wang, C., Wang, H., Wang, Q. et al. Int J Hematol (2013) 97: 240. doi:10.1007/s12185-013-1261-8 Abstract
To summarize the clinicopathological features, therapeutic regimens, and outcomes for patients with primary testicular lymphoma (PTL), we retrospectively reviewed the medical records of 13 patients diagnosed with PTL between 2001 and 2012 at our hospital. Average age at diagnosis was 62.2 ± 13.9 years, and all patients presented with painless testicular swelling. Diffuse large B-cell lymphoma was the dominant histotype (69.2 %). All 13 patients were treated with inguinal orchiectomy and received chemotherapy and/or radiotherapy. Complete follow-up data were available for 10 patients with an average follow-up duration of 28.4 ± 30.9 months. Seven patients were evaluated as Ann Arbor stage I or II, and three as stage III or IV. Eight patients were found to have hypoechogenic and hypervascular signals in the testis on ultrasound examination. Complete remission was achieved in six patients, and four patients who were still undergoing chemotherapy during the last follow-up showed no signs of relapse. Of the 10 patients with complete follow-up records, three had relapses, which occurred in the CNS, epiglottis, and the nasal cavity. Time to relapse in these cases was 2, 7, and 11 months, respectively (3/10). The mean progression-free survival was 22.57 months (range 1.1–101.9 months).
Keywords Primary testicular lymphoma Large B-cell lymphoma Testicular hydrocele Treatment Patient outcomes Abbreviations AFP
β-Human chorionic gonadotropin
Central nervous system
Diffuse large B-cell lymphoma
Dexamethasone, ifosfamide, cisplatin, and etoposide
Etoposide, solumedrol (methylprednisolone), ara-C (high-dose cytarabine), and cisplatin
International Prognostic Index
Magnetic resonance imaging
Primary testicular lymphoma
Electronic supplementary material
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) contains supplementary material, which is available to authorized users. 10.1007/s12185-013-1261-8 References
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