, Volume 96, Issue 2, pp 151-152
Date: 06 Aug 2012

Guest editorial: Introducing progress in hematology in this issue

This is an excerpt from the content

This issue of IJH contains five serial review articles on acute myeloid leukemia (AML). AML is a molecularly heterogeneous neoplasm, and the understanding of its molecular pathogenesis continues to grow. The development of chemotherapy and hematopoietic stem cell transplantation (HSCT) have increased 5-year survival rate to 40 % in AML patients younger than 60—65 years, whereas outcome in elderly AML patients remains dismal.

In the first review, David Grimwade summarizes the molecular heterogeneity of AML and clinical significance of each molecular abnormality. In his work with the UK Medical Research Council (MRC), he has published important articles on prognostic factors in AML and characterization of the mechanisms underlying leukemia-associated chromosomal translocations. A consensus had emerged that leukemogenesis requires two classes of mutations in AML (WHO classification 2008). The first of these is abnormalities in transcriptional factors that impair hematopoietic differentiati ...