International Journal of Hematology

, Volume 96, Issue 3, pp 342–349

Acute myeloid leukemia in clinical practice: a retrospective population-based cohort study in Miyazaki Prefecture, Japan

  • Takuya Matsunaga
  • Kiyoshi Yamashita
  • Yoko Kubuki
  • Takanori Toyama
  • Osamu Imataki
  • Kouichi Maeda
  • Noriaki Kawano
  • Seiichi Satou
  • Hiroshi Kawano
  • Junzo Ishizaki
  • Shuro Yoshida
  • Takuro Kameda
  • Tadashi Sasaki
  • Masaaki Sekine
  • Ayako Kamiunten
  • Yasuhiro Taniguchi
  • Tomonori Hidaka
  • Keiko Katayose
  • Haruko K-Shimoda
  • Kotaro Shide
  • Shojiro Yamamoto
  • Hiroshi Moritake
  • Hiroyuki Nunoi
  • Shigeyoshi Makino
  • Akira Kitanaka
  • Hitoshi Matsuoka
  • Kazuya Shimoda
Original Article

DOI: 10.1007/s12185-012-1146-2

Cite this article as:
Matsunaga, T., Yamashita, K., Kubuki, Y. et al. Int J Hematol (2012) 96: 342. doi:10.1007/s12185-012-1146-2

Abstract

We performed a retrospective population-based cohort study of acute myeloid leukemia (AML) in Miyazaki Prefecture, Japan. Over 6 years, we diagnosed 221 patients (211 adults and 10 children) with AML, indicating an incidence of AML in Miyazaki Prefecture of 3.2 per 100,000 per year. In 193 adult patients with non-acute promyelocytic leukemia (APL), the proportion of patients with myelodysplasia, unfavorable risk karyotypes, antecedent hematologic diseases, prior chemotherapy for other malignancies, and small proportion of blasts in the marrow was higher in patients ≥65 years, and patients with poor performance status (PS) and higher WBC counts at diagnosis were more prevalent among patients ≥75 years. One-third of the adult non-APL patients met the inclusion criteria usually applied in clinical trials: de novo AML, age ≤64 years with PS 0–2 and no key organ dysfunction. The 5-year overall survival (OS) rate of adult non-APL patients was 21.1 % (patients ≤64 years, 33.8 %; 65–74 years, 21.6 %; ≥75 years, 0 %). Multivariate analysis revealed that French-American-British subtypes M0, M6, and M7, poor PS (3, 4), unfavorable risk karyotypes, and higher WBC counts at diagnosis were independent adverse prognostic factors associated with OS. This analysis provides real world data.

Keywords

Acute myeloid leukemia (AML)Population-based studyClinical practice

Supplementary material

12185_2012_1146_MOESM1_ESM.tif (61 kb)
Supplemental Fig. 1. Negative correlation between performance status and intensity of induction chemotherapy in 108 non-acute promyelocytic leukemia patients aged ≥ 65 years. No shading, intensive chemotherapy; gray shading, less intensive chemotherapy; black shading, best supportive care (TIFF 60 kb)
12185_2012_1146_MOESM2_ESM.tif (60 kb)
Supplemental Fig. 2. Kaplan–Meier estimate of overall survival in 46 non-acute promyelocytic leukemia patients aged ≥ 70 years with PS 0–2 categorized by intensity of induction chemotherapy. Black line, intensive chemotherapy; gray line, less intensive chemotherapy (TIFF 59 kb)
12185_2012_1146_MOESM3_ESM.tif (71 kb)
Supplemental Table 1 (TIFF 71 kb)

Copyright information

© The Japanese Society of Hematology 2012

Authors and Affiliations

  • Takuya Matsunaga
    • 1
    • 4
  • Kiyoshi Yamashita
    • 2
  • Yoko Kubuki
    • 1
  • Takanori Toyama
    • 3
  • Osamu Imataki
    • 4
  • Kouichi Maeda
    • 5
  • Noriaki Kawano
    • 2
  • Seiichi Satou
    • 6
  • Hiroshi Kawano
    • 7
  • Junzo Ishizaki
    • 8
  • Shuro Yoshida
    • 2
  • Takuro Kameda
    • 1
  • Tadashi Sasaki
    • 3
  • Masaaki Sekine
    • 1
  • Ayako Kamiunten
    • 1
  • Yasuhiro Taniguchi
    • 1
  • Tomonori Hidaka
    • 1
  • Keiko Katayose
    • 1
  • Haruko K-Shimoda
    • 1
  • Kotaro Shide
    • 1
  • Shojiro Yamamoto
    • 1
  • Hiroshi Moritake
    • 9
  • Hiroyuki Nunoi
    • 9
  • Shigeyoshi Makino
    • 2
  • Akira Kitanaka
    • 1
  • Hitoshi Matsuoka
    • 7
  • Kazuya Shimoda
    • 1
  1. 1.Department of Gastroenterology and Hematology, Faculty of MedicineUniversity of MiyazakiMiyazakiJapan
  2. 2.Miyazaki Prefectural Miyazaki HospitalMiyazakiJapan
  3. 3.Miyazaki Prefectural Nobeoka HospitalNobeokaJapan
  4. 4.Division of Endocrinology and Metabolism, Hematology, Rheumatology and Respiratory Medicine, Department of Internal MedicineKagawa UniversityKagawaJapan
  5. 5.Miyakonojo National HospitalMiyakonojoJapan
  6. 6.Fujimoto Hayasuzu HospitalMiyakonojoJapan
  7. 7.Koga General HospitalMiyazakiJapan
  8. 8.Miyazaki Prefectural Nichinan HospitalNichinanJapan
  9. 9.Division of Pediatrics, Department of Reproductive and Developmental Medicine, Faculty of MedicineUniversity of MiyazakiMiyazakiJapan