International Journal of Hematology

, Volume 96, Issue 2, pp 254–262

Lenalidomide in combination with dexamethasone improves survival and time-to-progression in patients ≥65 years old with relapsed or refractory multiple myeloma

  • Asher A. Chanan-Khan
  • Sagar Lonial
  • Donna Weber
  • Ivan Borrello
  • Robin Foà
  • Andrzej Hellmann
  • Meletios Dimopoulos
  • Arlene S. Swern
  • Robert Knight
Original Article

DOI: 10.1007/s12185-012-1125-7

Cite this article as:
Chanan-Khan, A.A., Lonial, S., Weber, D. et al. Int J Hematol (2012) 96: 254. doi:10.1007/s12185-012-1125-7

Abstract

Two pivotal, phase III, randomised, placebo-controlled, registration trials (MM-009 and MM-010) showed that lenalidomide plus dexamethasone was more effective than placebo plus dexamethasone in the treatment of patients with relapsed or refractory multiple myeloma. This pooled, retrospective subanalysis of MM-009 and MM-010 analysed outcomes according to patient age. A total of 704 patients (390 aged <65 years, 232 aged 65–74 years, and 82 aged ≥75 years) received lenalidomide or placebo, both in combination with dexamethasone. The overall response rate (ORR) was significantly higher in patients treated with lenalidomide plus dexamethasone versus placebo plus dexamethasone in all age groups (P < 0.0001 for all). Median progression-free survival (PFS) and median time-to-progression (TTP) were similar, and both were significantly longer with lenalidomide plus dexamethasone in all age groups (P < 0.001 for all). Median overall survival (OS) favoured lenalidomide plus dexamethasone in all age groups, although the difference was not statistically significant. Adverse events of anaemia, febrile neutropenia, deep-vein thrombosis, neuropathy, and gastrointestinal disorders increased with age. Lenalidomide combined with dexamethasone improved the ORR and prolonged PFS, TTP, and OS compared with placebo plus dexamethasone, irrespective of age. This finding was consistent with the overall MM-009 and MM-010 populations.

Keywords

LenalidomideElderlyMultiple myelomaRelapsedRefractory

Copyright information

© The Japanese Society of Hematology 2012

Authors and Affiliations

  • Asher A. Chanan-Khan
    • 1
  • Sagar Lonial
    • 2
  • Donna Weber
    • 3
  • Ivan Borrello
    • 4
  • Robin Foà
    • 5
  • Andrzej Hellmann
    • 6
  • Meletios Dimopoulos
    • 7
  • Arlene S. Swern
    • 8
  • Robert Knight
    • 8
  1. 1.Department of MedicineRoswell Park Cancer Institute BuffaloBuffaloUSA
  2. 2.Emory Winship Cancer InstituteAtlantaUSA
  3. 3.M.D. Anderson Cancer CenterHoustonUSA
  4. 4.The Sidney Kimmel Comprehensive Cancer Center at Johns HopkinsBaltimoreUSA
  5. 5.Department of Cellular Biotechnologies and HematologySapienza University of RomeRomeItaly
  6. 6.Department of Hematology and TransplantologyMedical University of GdańskGdańskPoland
  7. 7.The University of Athens School of MedicineAthensGreece
  8. 8.Celgene CorporationSummitNJUSA