Progress in Hematology Disease modeling and treatment by iPS cells

International Journal of Hematology

, Volume 95, Issue 6, pp 617-623

First online:

Generation of mature hematopoietic cells from human pluripotent stem cells

  • Padma Priya TogarratiAffiliated withNational Primate Research Center, University of Wisconsin Graduate School Email author 
  • , Kran SuknunthaAffiliated withDepartment of Pathology and Laboratory Medicine, University of Wisconsin Medical SchoolDepartment of Pharmacology, Faculty of Science, Mahidol University

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Abstract

A number of malignant and non-malignant hematological disorders are associated with the abnormal production of mature blood cells or primitive hematopoietic precursors. Their capacity for continuous self-renewal without loss of pluripotency and the ability to differentiate into adult cell types from all three primitive germ layers make human embryonic stem cells and induced pluripotent stem cells (hiPSCs) attractive complementary cell sources for large-scale production of transfusable mature blood cell components in cell replacement therapies. The generation of patient-specific hematopoietic stem/precursor cells from iPSCs by the regulated manipulation of various factors involved in reprograming to ensure complete pluripotency, and developing innovative differentiation strategies for generating unlimited supply of clinically safe, transplantable, HLA-matched cells from hiPSCs to outnumber the inadequate source of hematopoietic stem cells obtained from cord blood, bone marrow and peripheral blood, would have a major impact on the field of regenerative and personalized medicine leading to translation of these results from bench to bedside.

Keywords

hiPSCs hESCs HSC Hematopoietic cells RBCs