International Journal of Hematology

, Volume 94, Issue 5, pp 453–460

The challenges of adherence and persistence with iron chelation therapy

  • John B. Porter
  • Michael Evangeli
  • Amal El-Beshlawy
Review Article

DOI: 10.1007/s12185-011-0927-3

Cite this article as:
Porter, J.B., Evangeli, M. & El-Beshlawy, A. Int J Hematol (2011) 94: 453. doi:10.1007/s12185-011-0927-3


Due to advances in medical sciences, many chronic diseases that formerly resulted in early death can now be effectively managed with long-term treatment regimens. Patients with potentially fatal anemias, for example, can be treated with ongoing blood transfusions and iron chelation therapy. Ensuring adherence and persistence is challenging, as the benefits of therapy are not perceived immediately. Poor adherence severely compromises the effectiveness of treatment and, therefore, improving compliance in terms of quality of life and health economics is critical. Although adherence to chelation therapy is generally poor, the availability of oral iron chelators may help to improve patient compliance. For chronic conditions such as thalassemia major, even when oral chelation therapy is available, support by an integrated team including a clinical psychologist and nurse specialist working with the treatment center is recommended to achieve optimal results.


Adherence Persistence Iron chelation therapy 

Copyright information

© The Japanese Society of Hematology 2011

Authors and Affiliations

  • John B. Porter
    • 1
  • Michael Evangeli
    • 2
  • Amal El-Beshlawy
    • 3
  1. 1.Department of HaematologyUniversity College London, UCL Cancer InstituteLondonUK
  2. 2.Royal HollowayUniversity of LondonLondonUK
  3. 3.Cairo UniversityCairoEgypt

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