International Journal of Hematology

, Volume 93, Issue 5, pp 677–680

Autologous stem cell transplantation in a rare multicentric Castleman disease of the plasma cell variant

Authors

  • Yuval Tal
    • Department of Internal Medicine CHadassah-Hebrew University Medical Center
  • Guy Haber
    • Department of Internal Medicine CHadassah-Hebrew University Medical Center
  • Matan J. Cohen
    • Department of Internal Medicine CHadassah-Hebrew University Medical Center
  • Micci Phillips
    • Department of Internal Medicine CHadassah-Hebrew University Medical Center
  • Gail Amir
    • Department of PathologyHadassah-Hebrew University Medical Center
  • Dina Ben-Yehuda
    • Department of HematologyHadassah-Hebrew University Medical Center
    • Department of Internal Medicine CHadassah-Hebrew University Medical Center
Case Report

DOI: 10.1007/s12185-011-0812-0

Cite this article as:
Tal, Y., Haber, G., Cohen, M.J. et al. Int J Hematol (2011) 93: 677. doi:10.1007/s12185-011-0812-0

Abstract

We present a case of a 52-year-old male who was evaluated due to anorexia, persistent diarrhea, weight loss, and liver enzyme elevations, with no hematologic laboratory abnormalities. Imaging modalities revealed several tissue lesions involving the pancreas, the right kidney, and an axillary lymph node. Diagnosis of Castleman disease was reached only due to the tissue obtained from the lymph node. Chemotherapy and immunosuppression led to a short remission. The patient underwent autologous stem cell transplantation, and has since been in remission. This case demonstrates the cryptogenic and chameleon-like nature of Castleman disease. Challenges in treating Castleman disease patients reflect current limitations and the need for a greater understanding of disease pathogenesis.

Keywords

Castleman disease Autologous stem cell transplantation

Abbreviations

CD

Castleman’s disease

MCD

Multicentric Castleman’s disease

HIV

Human immunodeficiency virus

CT

Computed tomography

PET

Positron emission tomography

Copyright information

© The Japanese Society of Hematology 2011