International Journal of Hematology

, Volume 91, Issue 5, pp 808–819

Differential effects of BAFF on B cell precursor acute lymphoblastic leukemia and Burkitt lymphoma

Authors

  • Keiko Onda
    • Department of Pediatric Hematology and Oncology ResearchNational Research Institute for Child Health and Development
    • Department of PediatricsJuntendo University, School of Medicine
  • Kazutoshi Iijima
    • Department of Pediatric Hematology and Oncology ResearchNational Research Institute for Child Health and Development
  • Yohko U. Katagiri
    • Department of Pediatric Hematology and Oncology ResearchNational Research Institute for Child Health and Development
  • Hajime Okita
    • Department of Pediatric Hematology and Oncology ResearchNational Research Institute for Child Health and Development
  • Masahiro Saito
    • Department of Pediatric Hematology and Oncology ResearchNational Research Institute for Child Health and Development
    • Department of PediatricsJuntendo University, School of Medicine
  • Toshiaki Shimizu
    • Department of PediatricsJuntendo University, School of Medicine
    • Department of Pediatric Hematology and Oncology ResearchNational Research Institute for Child Health and Development
Original Article

DOI: 10.1007/s12185-010-0567-z

Cite this article as:
Onda, K., Iijima, K., Katagiri, Y.U. et al. Int J Hematol (2010) 91: 808. doi:10.1007/s12185-010-0567-z

Abstract

B cell-activating factor belonging to the tumor necrosis factor superfamily (BAFF) is a crucial factor for B cell development and is involved in the survival of malignant B cells, but its effect on B cell precursors (BCPs) remains unclear. We investigated BCP acute lymphoblastic leukemia (-ALL) cells for BAFF receptor (-R) expression and compared the effect of BAFF on BCP-ALL cells and Burkitt lymphoma (BL) cells. Expression of BAFF-R was detected in some cell lines and some clinical specimens of both BL and BCP-ALL. BAFF acted on both BL and BCP-ALL cells and promoted proliferation by both. BAFF also inhibited apoptosis by BL cells induced by cross-linking of cell surface molecules and anticancer drugs, but failed to inhibit apoptosis by BCP-ALL cells. BAFF induced prompt and obvious activation of the NF-κB signaling pathway in BL cells, but only weak and delayed activation of the pathway in BCP-ALL cells. The results of this study indicate that some BCP-ALL cells and some BL cells express BAFF-R, but that the effects of BAFF on BCP-ALL cells are different from its effects on mature B cell malignancies.

Keywords

BAFFB cell precursor ALLBurkitt lymphomaApoptosis

Copyright information

© The Japanese Society of Hematology 2010