International Journal of Hematology

, Volume 91, Issue 3, pp 360–372

Pluripotency maintenance mechanism of embryonic stem cells and reprogramming

Progress in Hematology ES and iPS cells, attractive stem cells for regenerative medicine

DOI: 10.1007/s12185-010-0517-9

Cite this article as:
Masui, S. Int J Hematol (2010) 91: 360. doi:10.1007/s12185-010-0517-9


Embryonic stem (ES) cells are derived from blastocysts and are pluripotent. This pluripotency has attracted the interest of numerous researchers, both to expand our fundamental understanding of developmental biology and also because of potential applications in regenerative medicine. Systems biological studies have demonstrated that the pivotal transcription factors form a network. There they activate pluripotency-associated genes, including themselves, while repressing the developmentally regulated genes through co-occupation with various protein complexes. The chromatin structure characteristic of ES cells also contributes to the maintenance of the network. In this review, I focus on recent advances in our understanding of the transcriptional network that maintains pluripotency in mouse ES cells.


PluripotencyES cellsTranscriptional network

Copyright information

© The Japanese Society of Hematology 2010

Authors and Affiliations

  1. 1.Division of Molecular Biology and Cell Engineering, Department of Regenerative Medicine, Research Institute International Medical Center of JapanTokyoJapan
  2. 2.PRESTO, Japan Science and Technology AgencySaitamaJapan